FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Hsp22tetO.cBa
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General Information
Symbol
Dmel\Hsp22tetO.cBa
Species
D. melanogaster
Name
Tn10 tetracycline operator construct a of Bhole
FlyBase ID
FBal0269475
Feature type
allele
Associated gene
Dmel\Hsp22
Associated Insertion(s)
Carried in Construct
P{tetO-Hsp22.B}
Key Links
Transgenic product class
wild_type
(Bhole et al., 2004)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Bhole et al., 2004)
Mutagen
in vitro construct
(Bhole et al., 2004)
Progenitor genotype
Carried in construct
P{tetO-Hsp22.B}
Cytology
Description

tetO regulatory sequences drive expression of Hsp22.

(Bhole et al., 2004)
Allele components
Component
Use(s)
Regulatory region(s)
tetO
Encoded product / tool
Hsp22
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing Hsp22Tn10\tetO.cBa under the control of Tn10\tetRAct5C.T:Hsim\VP16 in the presence of doxycycline (DOX) show a significant decrease in survival when subjected to 36[o]C heat stress compared to controls.

      Flies expressing Hsp22Tn10\tetO.cBa under the control of Tn10\tetRAct5C.T:Hsim\VP16 in the presence of DOX show a significant decrease in resistance to paraquat compared to controls.

      Expression of Hsp22Tn10\tetO.cBa under the control of Tn10\tetRAct5C.T:Hsim\VP16 in the presence of DOX can result in a small decrease in lifespan at 25[o]C (depending on the Hsp22Tn10\tetO.cBa line used), and results in a greater reduction in lifespan compared to controls at 29[o]C.

      Expression of Hsp22Tn10\tetO.cBa under the control of Tn10\tetRAct5C.T:Hsim\VP16 in the presence of DOX has no effect on sensitivity to coumarin.

      (Bhole et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Hsp22Tn10\tetO.cBa
      Hsp22tetO.cBa
      Name Synonyms
      Tn10 tetracycline operator construct a of Bhole
      Secondary FlyBase IDs
        References (1)