FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\AGO1W894X
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General Information
Symbol
Dmel\AGO1W894X
Species
D. melanogaster
Name
FlyBase ID
FBal0269735
Feature type
allele
Associated gene
Dmel\AGO1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Pressman et al., 2012)
Mutagen
ethyl methanesulfonate
(Pressman et al., 2012)
Progenitor genotype
Cytology
Description

Nucleotide substitution: G?A.

(Pressman et al., 2012)

Amino acid replacement: W894term.

(Pressman et al., 2012)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:13,948,311..13,948,311 [-]
Nucleotide change:

G13948311A

Reported nucleotide change:

G?A

Amino acid change:

W894term | AGO1-PA; W860term | AGO1-PB; W894term | AGO1-PC; W894term | AGO1-PD

Reported amino acid change:

W894term

Comment:

TGG to TGA mutation in the Trp894 codon.

(Pressman et al., 2012)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Eyes entirely mutant for AGO1W894X (generated using the eyFLP method) are virtually completely lost. Hardly any eye tissue is seen at all.

      (Pressman et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Complements

      AGO1k08121

      (Pressman et al., 2012)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      AGO1W894X
      Ago1W894X
      (Pressman et al., 2012)
      W894X
      (Pressman et al., 2012)
      ago1W894
      (Cassidy et al., 2019)
      ago1W894X
      (Cassidy et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)