FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\GtpxlacZ
Open Close
General Information
Symbol
Dmel\GtpxlacZ
Species
D. melanogaster
Name
FlyBase ID
FBal0269815
Feature type
allele
Associated gene
Dmel\Gtpx
Associated Insertion(s)
Carried in Construct
P{Gtpx-lacZ}
Key Links
Transgenic product class
genomic_DNA
(Missirlis et al., 2003)
wild_type
(Missirlis et al., 2003)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Missirlis et al., 2003)
wild_type
(Missirlis et al., 2003)
Mutagen
in vitro construct
(Missirlis et al., 2003)
Progenitor genotype
Carried in construct
P{Gtpx-lacZ}
Cytology
Description

A 7kb genomic fragment containing the transcribed region of PHGPx as well as 5.5kb of upstream and 1kb of downstream sequences drives expression of Ecol\lacZ.

(Missirlis et al., 2003)
Allele components
Component
Use(s)
Regulatory region(s)
Gtpx
Encoded product / tool
Gtpx
Tagged with
lacZ
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Wild type flies expressing PHGPxT:Ecol\lacZ are more resistant to oxidative stress than controls. Unlike in wild type, up to 20% and 40% of flies expressing one or two copies of PHGPxT:Ecol\lacZ respectively are able to survive a paraquat concentration of 40nM. Flies are also more resistant to hypoxia treatment.

      (Missirlis et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Statement
      Reference

      GtpxlacZ is a non-suppressor of short lived phenotype of Catn1

      (Missirlis et al., 2003)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of either one or two copies of PHGPxT:Ecol\lacZ is unable to suppress the reduction in lifespan seen in Catn1 mutant flies.

      (Missirlis et al., 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      GtpxlacZ
      PHGPxT:Ecol\lacZ
      PHGPxlacZ
      Name Synonyms
      Secondary FlyBase IDs
        References (2)