FB2026_02 , released June 18, 2026
Allele: Dmel\Ngt-4-35
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General Information
Symbol
Dmel\Ngt-4-35
Species
D. melanogaster
Name
FlyBase ID
FBal0269856
Feature type
allele
Associated gene
Dmel\N
Associated Insertion(s)
Carried in Construct
P{N.gt-4_35}
PBac{N.gt-4_35}
Key Links
Transgenic product class
missense_variant
(Leonardi et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Leonardi et al., 2011)
Mutagen
in vitro construct
(Leonardi et al., 2011)
Progenitor genotype
N+t40
(Leonardi et al., 2011)
Carried in construct
P{N.gt-4_35}
PBac{N.gt-4_35}
Cytology
Description

Contains serine-to-alanine mutations in all of the EGF repeats of N to abolish the addition of O-glucose.

(Leonardi et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
N
Encoded product / tool
N
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      N55e11/Y ; Ngt-4-35 animals raised at 18[o]C do not show a rhabdomere attachment phenotype.

      (Haltom et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Ngt-4-35 is a suppressor | partially of visible | recessive phenotype of rumiΔ26

      (Leonardi et al., 2011)
      NOT Suppressor of
      Statement
      Reference

      Ngt-4-35 is a non-suppressor of lethal | heat sensitive phenotype of rumiΔ26

      (Leonardi et al., 2011)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Ngt-4-35 is a suppressor | partially of notal microchaeta phenotype of rumiΔ26

      (Leonardi et al., 2011)

      Ngt-4-35 is a suppressor | partially of leg phenotype of rumiΔ26

      (Leonardi et al., 2011)

      Ngt-4-35 is a suppressor | partially of leg joint phenotype of rumiΔ26

      (Leonardi et al., 2011)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Homozygous rumiΔ26 mutant animals also carrying Ngt-4-35 fail to reach the pharate adult stage when cultured at temperatures above 25 [o]C. Mutants cultured at room temperature (21-23 [o]C), similarly to rumiΔ26 single mutants, commonly exhibit mild defects in leg joints. At 18 [o]C, the mutants show a mild loss of microchaetae and normal legs.

      (Leonardi et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Ngt-4-35
      Name Synonyms
      Secondary FlyBase IDs
        References (2)