FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\MhcNIG.17927R
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General Information
Symbol
Dmel\MhcNIG.17927R
Species
D. melanogaster
Name
FlyBase ID
FBal0269878
Feature type
allele
Associated gene
Dmel\Mhc
Associated Insertion(s)
Carried in Construct
P{NIG.17927R}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Melkani et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Melkani et al., 2011)
Mutagen
in vitro construct
(Melkani et al., 2011)
Progenitor genotype
Carried in construct
P{NIG.17927R}
Cytology
Description

UASt regulatory sequences drive expression of an RNAi construct targeting Mhc.

(Melkani et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-17927R
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of MhcNIG.17927R under the control of Scer\GAL4tin.CΔ4 results in significantly decreased cardiac stiffness, cardiac dilation, impaired fractional shortening, decreased myocardial velocities, decreased heart rate and increased period, and significantly decreases median life span as compared to controls.

      (Kaushik et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Phenotype Manifest In
      Suppressed by
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of VincHP10347 in flies expressing MhcNIG.17927R under the control of Scer\GAL4tin.CΔ4 restores cardiac stiffness, heart period and median life span to wild type levels, partially restores the enlarged cardiac diameter and impaired fractional shortening, and leads to increased myocardial velocities and heart rate as compared with controls.

      (Kaushik et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      MhcNIG.17927R
      Name Synonyms
      Secondary FlyBase IDs
        References (3)