FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Ctr1BGMR.PS
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General Information
Symbol
Dmel\Ctr1BGMR.PS
Species
D. melanogaster
Name
FlyBase ID
FBal0270278
Feature type
allele
Associated gene
Dmel\Ctr1B
Associated Insertion(s)
Carried in Construct
P{GMR-Ctr1B.S}
Key Links
Transgenic product class
cDNA
(Saini et al., 2010)
wild_type
(Saini et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Saini et al., 2010)
wild_type
(Saini et al., 2010)
Mutagen
in vitro construct
(Saini et al., 2010)
Progenitor genotype
Carried in construct
P{GMR-Ctr1B.S}
Cytology
Description

GMR promoter sequences drive expression of Ctr1B cDNA sequences.

(Saini et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
GMR
Encoded product / tool
Ctr1B
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Ctr1BGMR.PS flies exhibit normal eyes when grown on normal food, but develop a rough eye phenotype in the presence of 20υM copper.

      (Saini et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Ctr1BGMR.PS has eye | chemical conditional phenotype, suppressible by park[+]/park25

      (Saini et al., 2010)
      NOT suppressed by
      Statement
      Reference

      Ctr1BGMR.PS has eye | chemical conditional phenotype, non-suppressible by park25

      (Saini et al., 2010)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Overexpression of Ctr1BGMR.PS in park25 homozygotes results in a rough eye phenotype. This phenotype can be alleviated by copper scarcity and exacerbated by increased copper levels. The rough eye phenotype is not seen upon expression of Ctr1BGMR.PS in a park25 heterozygous background.

      Overexpression of Ctr1BGMR.PS in park25 homozygotes raised on food supplemented with 20υM or 50υM silver nitrate fails to cause a rough eye phenotype, indicating that silver effectively competes with and inhibits copper import.

      (Saini et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Ctr1BGMR.PS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)