FlyBase Allele Report: Dmel\Pdzd8[NIG.10362R]

General Information

Symbol

Dmel\Pdzd8^NIG.10362R

Species

D. melanogaster

Name

FlyBase ID

FBal0270443

Feature type

allele

Associated gene

Dmel\Pdzd8

Associated Insertion(s)

Carried in Construct

P{NIG.10362R}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Japanese National Institute of Genetics, 2012.5.21)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Japanese National Institute of Genetics, 2012.5.21)

Mutagen

in vitro construct

(Japanese National Institute of Genetics, 2012.5.21)

Progenitor genotype

Carried in construct

P{NIG.10362R}

Cytology

Description

UASt regulatory sequences drive expression of a 500bp inverted repeat.

(Japanese National Institute of Genetics, 2012.5.21)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-10362R

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^{Arctic.UAS.Tag:SS(nec)}

(Hewitt et al., 2022)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage | progressive, with Scer\GAL4^nSyb.PS

(Hewitt et al., 2022)

abnormal neuroanatomy | larval stage, with Scer\GAL4^nSyb.PS

(Hewitt et al., 2022)

decreased size | larval stage, with Scer\GAL4^nSyb.PS

(Hewitt et al., 2022)

long lived, with Scer\GAL4^nSyb.PS

(Hewitt et al., 2022)

viable, with Scer\GAL4^nSyb.PS

(Hewitt et al., 2022)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Pdzd8^NIG.10362R, Scer\GAL4^nSyb.PS is a suppressor | partially of abnormal locomotor behavior | adult stage | progressive phenotype of Hsap\APP^{Arctic.UAS.Tag:SS(nec)}, Scer\GAL4^nSyb.PS

(Hewitt et al., 2022)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Pdzd8^NIG.10362R is rescued by Pdzd8^UAS.Tag:HA/Scer\GAL4^nSyb.PS

(Hewitt et al., 2022)

Rescues

Scer\GAL4^nSyb.PS/Pdzd8^NIG.10362R rescues Pdzd8^UAS.Tag:HA

(Hewitt et al., 2022)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

NIG-Fly

10362R-1

P{NIG.10362R}1

10362R-2

P{NIG.10362R}2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CG10362^NIG.10362R

Pdzd8^NIG.10362R

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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