FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Hsp83NIG.1242R
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General Information
Symbol
Dmel\Hsp83NIG.1242R
Species
D. melanogaster
Name
FlyBase ID
FBal0271247
Feature type
allele
Associated gene
Dmel\Hsp83
Associated Insertion(s)
Carried in Construct
P{NIG.1242R}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Japanese National Institute of Genetics, 2012.5.21)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Japanese National Institute of Genetics, 2012.5.21)
Mutagen
in vitro construct
(Japanese National Institute of Genetics, 2012.5.21)
Progenitor genotype
Carried in construct
P{NIG.1242R}
Cytology
Description

UASt regulatory sequences drive expression of a 500bp inverted repeat.

(Japanese National Institute of Genetics, 2012.5.21)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-1242R
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  carcinoma
      modeled by l(2)gl4, ykiUAS.cHa
      (Singh et al., 2022)
      modeled by l(2)gl4
      (Singh et al., 2022)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing Hsp83KK101256 under the control of either Scer\GAL4GMR.PU or Scer\GAL4ap-md544 exhibit cell cycle exit defects; an increased number of mitotic cells compared to controls are seen in the eyes and dorsal half of the wings respectively.

      (Bandura et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Pupal wings containing MARCM clones expressing Hsp83NIG.1242R under the control of Scer\GAL4Scer\FRT.Rnor\CD2.Act5C (co-expressing Dcr-2Scer\UAS.cDa, and BacA\p35Scer\UAS.cHa to inhibit apoptosis) have an increased mitotic index compared to controls.

      One copy of Df(2L)ED6569 suppresses the increased mitotic index seen in pupal wing clones expressing Hsp83NIG.1242R under the control of Scer\GAL4Scer\FRT.Rnor\CD2.Act5C (co-expressed with Dcr-2Scer\UAS.cDa and BacA\p35Scer\UAS.cHa).

      One copy of Rca12 suppresses the increased mitotic index seen in pupal wing clones expressing Hsp83NIG.1242R under the control of Scer\GAL4Scer\FRT.Rnor\CD2.Act5C (co-expressed with Dcr-2Scer\UAS.cDa and BacA\p35Scer\UAS.cHa).

      One copy of Rca1IX does not significantly suppress the increased mitotic index seen in pupal wing clones expressing Hsp83NIG.1242R under the control of Scer\GAL4Scer\FRT.Rnor\CD2.Act5C (co-expressed with Dcr-2Scer\UAS.cDa and BacA\p35Scer\UAS.cHa).

      (Bandura et al., 2013)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsp83NIG.1242R
      Hsp83RNAi
      (Singh et al., 2022)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)