FlyBase Allele Report: Dmel\nclb[NIG.6751R]

General Information

Symbol

Dmel\nclb^NIG.6751R

Species

D. melanogaster

Name

FlyBase ID

FBal0275275

Feature type

allele

Associated gene

Dmel\nclb

Associated Insertion(s)

Carried in Construct

P{NIG.6751R}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Japanese National Institute of Genetics, 2012.5.21)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Japanese National Institute of Genetics, 2012.5.21)

Mutagen

in vitro construct

(Japanese National Institute of Genetics, 2012.5.21)

Progenitor genotype

Carried in construct

P{NIG.6751R}

Cytology

Description

UASt regulatory sequences drive expression of a 500bp inverted repeat.

(Japanese National Institute of Genetics, 2012.5.21)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-6751R

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate | pupal stage, with Scer\GAL4^Cg.PA

(Liu et al., 2017)

abnormal size | adult stage, with Scer\GAL4^en-e16E

(Liu et al., 2017)

decreased body size | pupal stage, with Scer\GAL4^Cg.PA

(Liu et al., 2017)

Phenotype Manifest In

wing posterior compartment, with Scer\GAL4^en-e16E

(Liu et al., 2017)

Detailed Description

Statement

Reference

The expression of nclb^NIG.6751R under the control of Scer\GAL4^en-e16E leads to the wing posterior compartment exhibiting both a significant decrease in area and a small but significant increase in wing hair density, as compared to controls. Expression under the control of Scer\GAL4^Cg.PA leads to a significant delay in pupation, coupled with a significantly smaller pupal body size/volume, as compared to controls.

(Liu et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

nclb^NIG.6751R, Scer\GAL4^en-e16E is a suppressor of abnormal size | adult stage phenotype of InR^UAS.Exel, Scer\GAL4^en-e16E

(Liu et al., 2017)

nclb^NIG.6751R, Scer\GAL4^en-e16E is a suppressor of abnormal size | adult stage phenotype of Rheb^UAS.cPa, Scer\GAL4^en-e16E

(Liu et al., 2017)

nclb^NIG.6751R, Scer\GAL4^en-e16E is a suppressor of abnormal size | adult stage phenotype of Myc^UAS.cZa, Scer\GAL4^en-e16E

(Liu et al., 2017)

Phenotype Manifest In

Suppressor of

Statement

Reference

nclb^NIG.6751R, Scer\GAL4^Cg.PA is a suppressor of lipid droplet | increased number phenotype of Erk7^HMC04378, Scer\GAL4^Cg.PA

(Hasygar et al., 2021)

nclb^NIG.6751R, Scer\GAL4^Cg.PA is a suppressor of fat body phenotype of Erk7^HMC04378, Scer\GAL4^Cg.PA

(Hasygar et al., 2021)

nclb^NIG.6751R, Scer\GAL4^Cg.PA is a suppressor of nucleus phenotype of Erk7^HMC04378, Scer\GAL4^Cg.PA

(Hasygar et al., 2021)

nclb^NIG.6751R, Scer\GAL4^en-e16E is a suppressor of wing posterior compartment phenotype of InR^UAS.Exel, Scer\GAL4^en-e16E

(Liu et al., 2017)

nclb^NIG.6751R, Scer\GAL4^en-e16E is a suppressor of wing posterior compartment phenotype of Rheb^UAS.cPa, Scer\GAL4^en-e16E

(Liu et al., 2017)

nclb^NIG.6751R, Scer\GAL4^en-e16E is a suppressor of wing posterior compartment phenotype of Myc^UAS.cZa, Scer\GAL4^en-e16E

(Liu et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

The co-expression of nclb^NIG.6751R suppresses the increased wing posterior compartment area induced by the expression of InR^{Scer\UAS.Exel}, Rheb^Scer\UAS.cPa or Myc^Scer\UAS.cZa under the control of Scer\GAL4^en-e16E.

(Liu et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

NIG-Fly

6751R-1

P{NIG.6751R}1

6751R-3

P{NIG.6751R}3

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

nclb^NIG.6751R

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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