FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Pex3NIG.6859R
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General Information
Symbol
Dmel\Pex3NIG.6859R
Species
D. melanogaster
Name
FlyBase ID
FBal0275316
Feature type
allele
Associated gene
Dmel\Pex3
Associated Insertion(s)
Carried in Construct
P{NIG.6859R}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Japanese National Institute of Genetics, 2012.5.21)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Japanese National Institute of Genetics, 2012.5.21)
Mutagen
in vitro construct
(Japanese National Institute of Genetics, 2012.5.21)
Progenitor genotype
Carried in construct
P{NIG.6859R}
Cytology
Description

UASt regulatory sequences drive expression of a 500bp inverted repeat.

(Japanese National Institute of Genetics, 2012.5.21)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-6859R
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Zellweger syndrome
      CEA
      (Faust et al., 2014)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adults expressing Pex3NIG.6859R under the control of Scer\GAL4Act.PU exhibit increased mortality upon systemic infection with Drosophila C virus when compared to controls.

      (Merkling et al., 2019)

      Compared with wild-type, peroxisome abundance is reduced in wandering third instar larvae expressing Pex3NIG.6859R under the control of Scer\GAL4Act5C.PI.

      Peroxisome numbers are severely reduced in larval body wall muscles when Pex3NIG.6859R is driven by Scer\GAL4Mef2.PR compared with controls lacking Pex3NIG.6859R.

      (Faust et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of Dcr-2Scer\UAS.cDa results in lethality at the pharate adult stage in animals expressing Scer\GAL4Mef2.PR>Pex3NIG.6859R. Most of these pharate adults display signs of incomplete eclosion as indicated by an open operculum. Viability of Scer\GAL4Mef2.PR>Pex3NIG.6859R animals is reduced compared with animals expressing Scer\GAL4Mef2.PR>Dcr-2Scer\UAS.cDa alone. Wing expansion is also significantly impaired in animals co-expressing both Pex3NIG.6859R and Dcr-2Scer\UAS.cDa under the control of Scer\GAL4Mef2.PR. The eclosed mutants show impaired locomotion as determined by a climb test.

      (Faust et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Pex3NIG.6859R
      Name Synonyms
      Secondary FlyBase IDs
        References (3)