FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Mpc12
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General Information
Symbol
Dmel\Mpc12
Species
D. melanogaster
Name
FlyBase ID
FBal0276930
Feature type
allele
Associated gene
Dmel\Mpc1
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Bricker et al., 2012)
Progenitor genotype
Mpc1d00809
(Bricker et al., 2012)
Cytology
Description

Imprecise excision of the P{XP} element in P{XP}Mpc1d00809 results in a deletion.

(Bricker et al., 2012)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  mitochondrial pyruvate carrier deficiency
      CEA with Mpc11
      (Bricker et al., 2012)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mpc11/Mpc12 mutants are sensitive to a carbohydrate-only diet, dying shortly after transfer to a sucrose medium. The amount of adenosine 5'-triphosphate (ATP) is reduced, along with triacylglycerol (TAG) and protein. The amounts of carbohydrates are elevated, including the circulating sugars trehalose, glucose, fructose and glycogen. Pyruvate levels are elevated, whereas levels of TCA cycle intermediates (citrate, isocitrate, succinate, fumerate and malate) are reduced compared to controls. Increased levels of glycine and serine are seen and glutamate, aspartate and proline are all depleted.

      (Bricker et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Mpc12/Mpc11 is rescued by Scer\GAL4Tub.PU/Mpc1UAS.cBa

      (Bricker et al., 2012)

      Mpc12/Mpc11 is rescued by Scer\GAL4Cg.PA/Mpc1UAS.cBa

      (Bricker et al., 2012)

      Mpc12/Mpc11 is rescued by Scer\GAL4Mef2.PR/Mpc1UAS.cBa

      (Bricker et al., 2012)

      Mpc12/Mpc11 is rescued by Mpc1UAS.cBa/Scer\GAL4elav.PLu

      (Bricker et al., 2012)
      Not rescued by

      Mpc12/Mpc11 is not rescued by Scer\GAL4mex1.2.1/Mpc1UAS.cBa

      (Bricker et al., 2012)
      Comments

      Expression of Mpc1Scer\UAS.cBa under the control of Scer\GAL4tub.PU rescues the lethality seen in Mpc11/Mpc12 mutant flies on a sucrose diet. The lethality is also rescued when Mpc1Scer\UAS.cBa is expressed in the fat body (Scer\GAL4Cg.PA), muscle (Scer\GAL4Mef2.PR) or neurons (Scer\GAL4elav.PLu). No rescue is seen when Mpc1Scer\UAS.cBa is expressed in the gut under the control of Scer\GAL4mex1.2.1.

      (Bricker et al., 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Mpc12
      dMPC12
      (Schell et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)