FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\cmetA3G1
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General Information
Symbol
Dmel\cmetA3G1
Species
D. melanogaster
Name
FlyBase ID
FBal0277085
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Progenitor genotype
Cytology
Description

A 111bp insertion within the kinesin motor domain of cmet causes a frameshift and a premature stop codon.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous cmetA3G1 mutant eyes show moderate defects in compensatory growth in response to tissue loss (induced by generating larval clones of the temperature-sensitive cell-lethal mutation sec5ts1 under the control of Scer\GAL4en-e16E at the restrictive temperature). The resulting eyes are smaller than wild type. Moderate defects in cell proliferation are also detected when the sec5ts1 cells are not ablated (i.e. when the flies are maintained at the permissive temperature). The proportion of mutant eye tissue seen following generation of wild type non-ablating clones is similar at 25[o]C and 30[o]C suggesting the mutation is not temperature sensitive. cmetA3G1 mutant eyes show moderate growth defects when tissue is ablated during the larval stages using irradiation.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
cmetA3G1
Name Synonyms
Secondary FlyBase IDs
    References (1)