FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\PICK1ΔEP-147
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General Information
Symbol
Dmel\PICK1ΔEP-147
Species
D. melanogaster
Name
FlyBase ID
FBal0277139
Feature type
allele
Associated gene
Dmel\PICK1
Associated Insertion(s)
Carried in Construct
Also Known As
PICK11
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Jansen et al., 2009)
Progenitor genotype
IFT43EP2315
(Jansen et al., 2009)
Cytology
Description

Mobilisation of P{EP}CG5780EP2315 (inserted into the 5'UTR of CG5780) results in deletion of the 5' end of the PICK1 open reading frame, including the two first exons.

(Jansen et al., 2009)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Machado-Joseph disease
      modeled by Hsap\ATXN3tr.Q78.UAS.Tag:HA
      (McGurk and Bonini, 2012)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adult female and male PICK1ΔEP-147 homozygotes or PICK1ΔEP-147/PICK1ΔEP-197 transheterozygotes exhibit significant weight loss compared to controls.

      (Holst et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      PICK1ΔEP-197/PICK1ΔEP-147 is rescued by Scer\GAL4dimm-929/PICK1UAS.A.Tag:HA

      (Holst et al., 2013)

      PICK1ΔEP-197/PICK1ΔEP-147 is rescued by Scer\GAL4Ilp2.PR/PICK1UAS.A.Tag:HA

      (Holst et al., 2013)
      Comments

      Scer\GAL4dimm-929-mediated expression of PICK1Scer\UAS.A.T:Ivir\HA1 fully rescues the weight loss seen in PICK1ΔEP-147/PICK1ΔEP-197 adult females and males.

      Scer\GAL4Ilp2.PR-mediated expression of PICK1Scer\UAS.A.T:Ivir\HA1 rescues the weight loss seen in PICK1ΔEP-147/PICK1ΔEP-197 adult females but not males.

      (Holst et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      In addition to the PICK1 gene, PICK1ΔEP-147 covers most of CG5781.

      (Jansen et al., 2009)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      PICK11
      (Lund et al., 2021, Herlo et al., 2018, Holst et al., 2013)
      PICK1delEP147
      (McGurk and Bonini, 2012)
      PICK1ΔEP-147
      (Jansen et al., 2009)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)