FlyBase Allele Report: Dmel\Plzf[UAS.cMa]

General Information

Symbol

Dmel\Plzf^UAS.cMa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Maeng

FlyBase ID

FBal0277147

Feature type

allele

Associated gene

Dmel\Plzf

Associated Insertion(s)

Carried in Construct

P{UAS-Plzf.M}

Key Links

Transgenic product class

cDNA

(Maeng et al., 2012)

wild_type

(Maeng et al., 2012)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Maeng et al., 2012)

wild_type

(Maeng et al., 2012)

Mutagen

in vitro construct

(Maeng et al., 2012)

Progenitor genotype

Carried in construct

P{UAS-Plzf.M}

Cytology

Description

UASt drives expression of the Plzf SD03430 cDNA.

(Maeng et al., 2012)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Plzf

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

wing vein | ectopic | increased number, with Scer\GAL4^Bx-MS1096

(Maeng et al., 2012)

wing vein | ectopic | increased number, with Scer\GAL4^en-e16E

(Maeng et al., 2012)

Detailed Description

Statement

Reference

Expression of Plzf^Scer\UAS.cMa using Scer\GAL4^en-e16E or Scer\GAL4^Bx-MS1096 generates extra and ectopic veins in various wing regions, and also causes a distorted wing shape when present in two copies.

(Maeng et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Plzf^UAS.cMa, Raf^UAS.F179, Scer\GAL4^Bx-MS1096 has lethal | pupal stage phenotype

(Maeng et al., 2012)

Phenotype Manifest In

Enhanced by

Statement

Reference

Plzf^UAS.cMa, Scer\GAL4^Bx-MS1096 has wing vein | ectopic | increased number phenotype, enhanceable by Ras85D^V12.UAS, Scer\GAL4^Bx-MS1096

(Maeng et al., 2012)

Plzf^UAS.cMa, Scer\GAL4^Bx-MS1096 has wing vein | ectopic | increased number phenotype, enhanceable by rl^UAS.cKa, Scer\GAL4^Bx-MS1096

(Maeng et al., 2012)

Enhancer of

Statement

Reference

Plzf^UAS.cMa, Scer\GAL4^Bx-MS1096 is an enhancer of wing vein | ectopic | increased number phenotype of Ras85D^V12.UAS, Scer\GAL4^Bx-MS1096

(Maeng et al., 2012)

Plzf^UAS.cMa, Scer\GAL4^Bx-MS1096 is an enhancer of wing vein | ectopic | increased number phenotype of Scer\GAL4^Bx-MS1096, rl^UAS.cKa

(Maeng et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Scer\GAL4^Bx-MS1096-mediated expression of both Ras85D^V12.Scer\UAS and Plzf^Scer\UAS.cMa generates significantly enhanced extra and ectopic veins as compared to expression of either transgene alone. This effect is more dramatic at 18[o]C than 25[o]C.

Scer\GAL4^Bx-MS1096-mediated expression of both rl^Scer\UAS.cKa and Plzf^Scer\UAS.cMa generates significantly enhanced extra and ectopic veins as compared to expression of either transgene alone. This effect is more dramatic at 18[o]C than 25[o]C.

Flies that co-express phl^{Scer\UAS.F179} and Plzf^Scer\UAS.cMa under the control of Scer\GAL4^Bx-MS1096 die at the pupal stage due to wing malformation.

(Maeng et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

Plzf^UAS.cMa is partially rescued by Scer\GAL4^Bx-MS1096/Plzf^KK106394

(Maeng et al., 2012)

Comments

Co-expression of Plzf^KK106394 significantly reduces the extra and ectopic veins generated by Scer\GAL4^Bx-MS1096-mediated expression of Plzf^Scer\UAS.cMa.

(Maeng et al., 2012)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Plzf^Scer\UAS.cMa

Plzf^UAS.cMa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Maeng

Secondary FlyBase IDs

References (1)

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