FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Mps1UAS.cAa
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General Information
Symbol
Dmel\Mps1UAS.cAa
Species
D. melanogaster
Name
FlyBase ID
FBal0277472
Feature type
allele
Associated gene
Dmel\Mps1
Associated Insertion(s)
Carried in Construct
P{UAS-Mps1.A}
Key Links
Transgenic product class
wild_type
(Althoff et al., 2012)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Althoff et al., 2012)
Mutagen
in vitro construct
(Althoff et al., 2012)
Progenitor genotype
Mps1UAS.EGFP
(Althoff et al., 2012)
Carried in construct
P{UAS-Mps1.A}
Cytology
Description

UASt regulatory sequences drive expression of untagged Mps1.

(Althoff et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Mps1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of aldScer\UAS.cAa under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16 results in delayed progression through mitosis 14 metaphase. Chromosome condensation and congression into the metaphase plate proceeds with the same speed as control embryos, but metaphase is ~10 times longer. The remainder of mitosis then occurs with similar kinetics to wild type. The metaphase plate is not widened compared to controls and the separation between sister kinetochores also appears normal.

      (Althoff et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The presence of a TEV protease cleavable form of vtd (by expressing vtd271TEV.tub.T:Zzzz\TEV.CS,T:Hsap\MYC and Zzzz\NIaScer\UAS.T:SV5\V5,T:SV40\nls2 in a vtdex3 mutant background) suppresses the chromosome segregation defects seen in embryos expressing aldScer\UAS.cAa under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16 in a mad2G6595 mutant background. This suppression does not occur in the absence of Zzzz\NIaScer\UAS.T:SV5\V5,T:SV40\nls2.

      (Althoff et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Mps1Scer\UAS.cAa
      Mps1UAS.cAa
      aldScer\UAS.cAa
      Name Synonyms
      Secondary FlyBase IDs
        References (1)