FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\DCTN1-p150G50A.UAS.Tag:HA
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General Information
Symbol
Dmel\DCTN1-p150G50A.UAS.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0277617
Feature type
allele
Associated gene
Dmel\DCTN1-p150
Associated Insertion(s)
Carried in Construct
P{UAS-DCTN1-p150.G50A.HA}
Key Links
Genomic Maps

Transgenic product class
missense_variant
(Lloyd et al., 2012)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Lloyd et al., 2012)
Mutagen
in vitro construct
(Lloyd et al., 2012)
Progenitor genotype
Carried in construct
P{UAS-DCTN1-p150.G50A.HA}
Cytology
Description

UAS regulatory sequences drive expression of DCTN1-p150 containing the amino acid replacement G50A. The protein is also tagged with a Tag:HA epitope.

(Lloyd et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
DCTN1-p150
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:13,929,997..13,929,997 [+]
Nucleotide change:

G13929997C

Amino acid change:

G50A | DCTN1-p150-PA

Reported amino acid change:

G50A

Comment:

Mutation in analogous codon in human DCTN1 implicated in Perry syndrome; mutation carried on in vitro construct; site of nucleotide substitution in fly gene inferred by FlyBase curator based on reported amino acid change.

(Lloyd et al., 2012)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (Lloyd et al., 2012)
      DCTN1:p.Gly71Ala
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      DCTN1:p.Gly54Ala
      Associated human disease model(s)
      External database links
      ClinVar: DCTN1_21391
      Comments concerning this variant
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      The protein produced carries the G50A mutation, which is equivalent to the human Perry syndrome mutation G71A.

      (Lloyd et al., 2012)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      DCTN1-p150G50A.Scer\UAS.T:Ivir\HA1
      DCTN1-p150G50A.UAS.Tag:HA
      GlG50A.Scer\UAS.T:Ivir\HA1
      p150G50A-HA
      (Lloyd et al., 2012)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)