FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\SbfUAS.mCherry
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General Information
Symbol
Dmel\SbfUAS.mCherry
Species
D. melanogaster
Name
FlyBase ID
FBal0277633
Feature type
allele
Associated gene
Dmel\Sbf
Associated Insertion(s)
Carried in Construct
P{UAS-Sbf.mCherry}
Key Links
Transgenic product class
cDNA
(Jean et al., 2012)
wild_type
(Jean et al., 2012)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Jean et al., 2012)
wild_type
(Jean et al., 2012)
Mutagen
in vitro construct
(Jean et al., 2012)
Progenitor genotype
Carried in construct
P{UAS-Sbf.mCherry}
Cytology
Description

UAS sequences drive expression of a full-length Sbf cDNA tagged with mCherry.

(Jean et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Sbf
Tagged with
mCherry
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Primary macrophages isolated from animals expressing SbfScer\UAS.T:Disc\RFP-mCherry under the control of Scer\GAL4Cg.PA have an increased number of F-actin rich protrusions per cell compared to controls.

      (Jean et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of mtmdsRNA.cVa.Scer\UAS suppresses the excess F-actin rich protrusions seen in macrophages isolated from animals expressing SbfScer\UAS.T:Disc\RFP-mCherry under the control of Scer\GAL4Cg.PA. The macrophages display unextended F-actin fibers.

      Primary macrophages isolated from animals expressing mtmN.Scer\UAS.T:Avic\GFP-EGFP and SbfScer\UAS.T:Disc\RFP-mCherry under the control of Scer\GAL4Cg.PA have an increased number of F-actin rich protrusions per cell compared to controls.

      Expression of Pi3K68DGD7348 suppresses the excess F-actin rich protrusions seen in macrophages isolated from animals expressing SbfScer\UAS.T:Disc\RFP-mCherry under the control of Scer\GAL4Cg.PA.

      Expression of Rab21T27N.Scer\UAS.T:Avic\GFP suppresses the excess F-actin rich protrusions seen in macrophages isolated from animals expressing SbfScer\UAS.T:Disc\RFP-mCherry under the control of Scer\GAL4Cg.PA.

      Expression of Rab21GD9042 suppresses the excess F-actin rich protrusions seen in macrophages isolated from animals expressing SbfScer\UAS.T:Disc\RFP-mCherry under the control of Scer\GAL4Cg.PA.

      (Jean et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      SbfUAS.mCherry is rescued by Scer\GAL4Cg.PA/SbfGD12081

      (Jean et al., 2012)
      Comments

      Expression of SbfGD12081 rescues the excess F-actin rich protrusions seen in macrophages isolated from animals expressing SbfScer\UAS.T:Disc\RFP-mCherry under the control of Scer\GAL4Cg.PA.

      (Jean et al., 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      SbfScer\UAS.T:Disc\RFP-mCherry
      SbfUAS.mCherry
      Name Synonyms
      Secondary FlyBase IDs
        References (1)