FlyBase Allele Report: Dmel\Sarm[4705]

General Information

Symbol

Dmel\Sarm⁴⁷⁰⁵

Species

D. melanogaster

Name

FlyBase ID

FBal0277678

Feature type

allele

Associated gene

Dmel\Sarm

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Amino acid replacement: Q681term.

(Osterloh et al., 2012)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:8,103,532..8,103,532 [+]

Nucleotide change:

C8103532T

Amino acid change:

Reported amino acid change:

Q681term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Osterloh et al., 2012)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell number | embryonic stage (with Sarm⁴⁶²¹)

(Foldi et al., 2017)

Phenotype Manifest In

larval central nervous system | embryonic stage (with Sarm⁴⁶²¹)

(Foldi et al., 2017)

neuron | embryonic stage | increased number (with Sarm⁴⁶²¹)

(Foldi et al., 2017)

Detailed Description

Statement

Reference

Ect4⁴⁷⁰⁵/Ect4⁴⁶²¹ mutant embryos have more eve-positive neurons in the central nervous system compared to wild-type controls.

(Foldi et al., 2017)

The axons of homozygous olfactory receptor neurons remain intact 1 week after axon severing (in contrast to wild type).

(Osterloh et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Sarm⁴⁶²¹/Sarm⁴⁷⁰⁵ is a suppressor of abnormal neuroanatomy | larval stage phenotype of Nmnat^U6:3.gRNA, Spyo\Cas9^ppk.PP

(Ji et al., 2022)

Sarm⁴⁶²¹/Sarm⁴⁷⁰⁵ is a suppressor of decreased size | larval stage phenotype of Nmnat^U6:3.gRNA, Spyo\Cas9^ppk.PP

(Ji et al., 2022)

Phenotype Manifest In

Suppressor of

Statement

Reference

Sarm⁴⁶²¹/Sarm⁴⁷⁰⁵ is a suppressor of dendrite | larval stage phenotype of Nmnat^U6:3.gRNA, Spyo\Cas9^ppk.PP

(Ji et al., 2022)

Sarm⁴⁶²¹/Sarm⁴⁷⁰⁵ is a suppressor of larval dorsal multidendritic neuron ddaC phenotype of Nmnat^U6:3.gRNA, Spyo\Cas9^ppk.PP

(Ji et al., 2022)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Ect4⁴⁷⁰⁵

Sarm⁴⁷⁰⁵

(Ji et al., 2022)

dsarm⁴⁷⁰⁵

(Foldi et al., 2017)

l(3)4705

(Osterloh et al., 2012)

sarm⁴⁷⁰⁵

(Brace et al., 2022)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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