FB2026_02 , released June 18, 2026
Allele: Dmel\fonΔ17A
Open Close
General Information
Symbol
Dmel\fonΔ17A
Species
D. melanogaster
Name
FlyBase ID
FBal0277714
Feature type
allele
Associated gene
Dmel\fon
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
minos activity
(Bajzek et al., 2012)
Progenitor genotype
Mi{ET1}CG17350MB01546
(Bajzek et al., 2012)
Cytology
Description

Imprecise excision of the progenitor insertion, resulting in deletion of fon sequence without affecting CG17350 exons.

(Bajzek et al., 2012)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      fonΔ17A homozygous and fonΔ17A/Df(2L)Exel6043 transheterozygous pupae are elongated, as shown by a significant increase in the length/width axial ratio as compared to controls.

      fonΔ17A/Df(2L)Exel6043 transheterozygous wandering third instar larvae present significant detachment of myofibers and a significant increase in the hemisegmental gap between dorsal oblique muscles 1 and 2, as compared to controls; type I synapses enervating lateral longitudinal muscle 1 present similar bouton number, as compared to controls.

      At the muscle attachment sites of fonΔ17A/Df(2L)Exel6043 transheterozygous wandering third instar larvae, muscle and tendons are adjacent but not interdigitated and there is decreased amount of extracellular matrix in-between, tendon cells display a decrease in junctional complexes, and muscle attachment fibers present a convoluted arrangement, as compared to controls.

      (Green et al., 2016)

      Hemolymph from homozygous wandering larvae produces longer fibres than can be drawn from wild-type larvae in a drawout assay testing coagulation.

      (Bajzek et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      fonΔ17A is partially rescued by fonUAS.EGFP/Scer\GAL4da.G32

      (Bajzek et al., 2012)
      Comments

      Expression of fonScer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4da.G32 partially rescues the lethality of fonΔ17A homozygotes. However, the increased strand length that can be drawn out from the larval hemolymph in a drawout assay testing coagulation is not rescued in these animals.

      (Bajzek et al., 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      fonΔ17
      (Green et al., 2016)
      fonΔ17A
      Δ17A
      (Bajzek et al., 2012)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)