FB2026_02 , released June 18, 2026
Allele: Dmel\Nep4HQxxH.UAS.A
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General Information
Symbol
Dmel\Nep4HQxxH.UAS.A
Species
D. melanogaster
Name
FlyBase ID
FBal0277822
Feature type
allele
Associated gene
Dmel\Nep4
Associated Insertion(s)
Carried in Construct
P{UAS-Nep4.A.HQxxH}
Also Known As
UAS-Nep4Ainact
Key Links
Transgenic product class
missense_variant
(Panz et al., 2012)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Panz et al., 2012)
Mutagen
in vitro construct
(Panz et al., 2012)
Progenitor genotype
Carried in construct
P{UAS-Nep4.A.HQxxH}
Cytology
Description

UAS regulatory sequences drive expression of the Nep4 A isoform which carries the amino acid replacement E873Q in the conserved HExxH motif, which is predicted to result in a catalytically inactive protein.

(Panz et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Nep4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Third instar larvae expressing Nep4HQxxH.Scer\UAS.A under the control of Scer\GAL4Mef2.5xCD show muscle degeneration.

      (Panz et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Nep4HQxxH.Scer\UAS.A
      Nep4HQxxH.UAS.A
      Name Synonyms
      Secondary FlyBase IDs
        References (3)