Expression of FIG4^HMS01749 driven by Scer\GAL4^elav.PLu have significantly shorter life spans and show locomotion defects (reduced climbing ability at 3 days old, more prominent reductions at 14 days old) compared to control flies, and total synaptic branch length of motor neurons at the neuromuscular junction is significantly decreased in third instar larvae.

Flies with expression of FIG4^HMS01749 driven by Scer\GAL4^GMR.PU have a rough eye phenotype, with fusion of ommatidia and a lack of bristles; all 8 photoreceptor cells appear to differentiate normally, though there are some marginal photoreceptor axonal targeting aberrations in eye imaginal discs.