FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Vps13DHMS01784
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General Information
Symbol
Dmel\Vps13DHMS01784
Species
D. melanogaster
Name
FlyBase ID
FBal0278902
Feature type
allele
Associated gene
Dmel\Vps13D
Associated Insertion(s)
Carried in Construct
P{TRiP.HMS01784}
Also Known As
Vps13D RNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Ni et al., 2010.12.1)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Ni et al., 2010.12.1)
Mutagen
in vitro construct
(Ni et al., 2010.12.1)
Progenitor genotype
Carried in construct
P{TRiP.HMS01784}
Cytology
Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-HMS01784
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The cell size in pupal (2hr after pupariation) midgut somatic clones expressing Vps13DHMS01784 under the control of Scer\GAL4Scer\FRT.Rnor\Cd2.Act5C is significantly increased and the cells contain fewer Atg8a puncta compared to control cells.

      (Anding et al., 2018)

      Expressing Vps13DHMS01784 under the control of Scer\GAL4Toll-6-D42 results in a loss of complexity of the mitochondria network in the larval brain; in addition, there is a strong impairment in the distribution of mitochondria in peripheral axons in segmental nerves and neuromuscular junction synapses - the density of mitochondria is progressively reduced concomitant with increased distance from the cell body.

      (Seong et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CG32113HMS01784
      Vps13DHMS01784
      Name Synonyms
      Secondary FlyBase IDs
        References (9)