FlyBase Allele Report: Dmel\if[HMS01872]

General Information

Symbol

Dmel\if^HMS01872

Species

D. melanogaster

Name

FlyBase ID

FBal0278989

Feature type

allele

Associated gene

Dmel\if

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS01872}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS01872}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS01872

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Huntington's disease

modeled by Hsap\HTT^{128Q.1-231.UAS}

(Hernandez et al., 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neurophysiology | larval stage, with Scer\GAL4^BG380

(Wang et al., 2018)

abnormal neurophysiology | larval stage, with Scer\GAL4^how-24B

(Wang et al., 2018)

Phenotype Manifest In

embryonic/larval neuromuscular junction | larval stage, with Scer\GAL4^BG380

(Wang et al., 2018)

embryonic/larval neuromuscular junction | larval stage, with Scer\GAL4^how-24B

(Wang et al., 2018)

Detailed Description

Statement

Reference

The expression of if^HMS01872 leads to defects in neurotransmission across the muscle 6 neuromuscular junction: a significant decrease in mEJP frequency and amplitude (Scer\GAL4^BG380-driven expression); a significant decrease in mEJP amplitude, but not frequency (Scer\GAL4^how-24B-driven expression).

(Wang et al., 2018)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

if^HMS01872, Scer\GAL4^elav-C155 is a non-enhancer of decreased rate of adult locomotory behavior | progressive phenotype of Hsap\HTT^{128Q.1-231.UAS}, Scer\GAL4^elav-C155

(Hernandez et al., 2023)

Suppressor of

Statement

Reference

if^HMS01872, Scer\GAL4^repo is a suppressor of decreased rate of adult locomotory behavior phenotype of Hsap\HTT^{128Q.1-231.UAS}, Scer\GAL4^repo

(Hernandez et al., 2023)

NOT Suppressor of

Statement

Reference

if^HMS01872, Scer\GAL4^elav-C155 is a non-suppressor of decreased rate of adult locomotory behavior | progressive phenotype of Hsap\HTT^{128Q.1-231.UAS}, Scer\GAL4^elav-C155

(Hernandez et al., 2023)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

38958

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01872}attP40/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

if^HMS01872

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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