FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\stasUAS.cLa
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General Information
Symbol
Dmel\stasUAS.cLa
Species
D. melanogaster
Name
FlyBase ID
FBal0280065
Feature type
allele
Associated gene
Dmel\stas
Associated Insertion(s)
Carried in Construct
P{UAS-stas.L}
Key Links
Transgenic product class
cDNA
(Lotti et al., 2012)
wild_type
(Lotti et al., 2012)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Lotti et al., 2012)
wild_type
(Lotti et al., 2012)
Mutagen
in vitro construct
(Lotti et al., 2012)
Progenitor genotype
Carried in construct
P{UAS-stas.L}
Cytology
Description

UAS regulatory sequences drive expression of a stas cDNA (LD12309)

(Lotti et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
stas
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of stasScer\UAS.cLa under the control of Scer\GAL4n-syb.PS has no effect on neuromuscular junction evoked excitatory postsynaptic potential (eEPSP) amplitude compared to controls.

      (Lotti et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of stasScer\UAS.cLa either pan-neuronally under the control of Scer\GAL4n-syb.PS or in cholinergic neurons using Scer\GAL4Cha.7.4 rescues the increase in neuromuscular junction evoked excitatory postsynaptic potential (eEPSP) amplitudes seen in SmnX7 mutant larvae. The reduction in muscle size is rescued to 80% of that in control larvae. Expression of stasScer\UAS.cLa in the glutamatergic motor neurons using the Scer\GAL4VGlut-OK371 driver fails to rescue either the eEPSP or muscle size phenotypes. The locomotor activity defects seen in SmnX7 mutants are not rescued by any of the three drivers.

      (Lotti et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      stasUAS.cLa/Scer\GAL4nSyb.PS rescues stasEY04008

      (Lotti et al., 2012)
      Comments

      Expression of stasScer\UAS.cLa under the control of Scer\GAL4n-syb.PS rescues the increase in evoked excitatory postsynaptic potential amplitudes at the neuromuscular junctions of stasEY04008 mutant larvae.

      (Lotti et al., 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      stasScer\UAS.cLa
      stasUAS.cLa
      Name Synonyms
      Secondary FlyBase IDs
        References (1)