FB2026_03 , released September 17, 2026
Allele: Dmel\His2AvS137E.UAS
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General Information
Symbol
Dmel\His2AvS137E.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0280097
Feature type
allele
Associated gene
Dmel\His2Av
Associated Insertion(s)
Carried in Construct
P{UAS-His2Av.S137E}
Key Links
Transgenic product class
missense_variant
(Kotova et al., 2011)
polypeptide_post_translational_processing_variant
(Kotova et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Kotova et al., 2011)
polypeptide_post_translational_processing_variant
(Kotova et al., 2011)
Mutagen
in vitro construct
(Kotova et al., 2011)
Progenitor genotype
Carried in construct
P{UAS-His2Av.S137E}
Cytology
Description

UASt regulatory sequences drive expression of full-length His2Av that has been mutated to carry a S137E amino acid replacement (phosphomimetic mutation at a phosphorylation site).

(Kotova et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
His2Av
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      His2AvS137E.UAS/Scer\GAL4arm.PS rescues His2Av810

      (Kotova et al., 2011)
      Comments

      Expression of His2AvS137E.Scer\UAS under the control of Scer\GAL4arm.PS rescues the viability of His2Av810 flies exposed to 36Gy (gamma irradiation).

      (Kotova et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      His2AvS137E.Scer\UAS
      His2AvS137E.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)