FlyBase Allele Report: Dmel\Hsl[b24]

General Information

Symbol

Dmel\Hsl^b24

Species

D. melanogaster

Name

FlyBase ID

FBal0280215

Feature type

allele

Associated gene

Dmel\Hsl

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Bi et al., 2012)

Progenitor genotype

P{EPgy2}Hsl^EY20067

(Bi et al., 2012)

Cytology

Description

Imprecise excision of the progenitor insertion, resulting in a 472bp deletion which includes the Hsl start codon.

(Bi et al., 2012)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

embryonic/larval fat body | larval stage

(Bi et al., 2012)

lipid droplet

(Bi et al., 2012)

Detailed Description

Statement

Reference

Mutant larvae have slightly larger lipid droplets in the fat body than normal under fed conditions. Under starvation conditions, the lipid droplets in the mutant fat bodies are significantly larger than those in the wild-type controls.

Mutant third instar larvae show a 30% increase in the total glyceride level compared to wild type under fed conditions. Under starvation conditions, the level of total glyceride in the mutant larvae is double the level in the wild-type controls.

(Bi et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

Hsl^b24 has embryonic/larval fat body | larval stage phenotype, enhanceable by bmm¹

(Bi et al., 2012)

Hsl^b24 has lipid droplet phenotype, enhanceable by bmm¹

(Bi et al., 2012)

Enhancer of

Statement

Reference

Hsl^b24 is an enhancer of embryonic/larval fat body | larval stage phenotype of Lsd1³⁸

(Bi et al., 2012)

Hsl^b24 is an enhancer of lipid droplet phenotype of Lsd1³⁸

(Bi et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

The increase in size of the lipid droplets in the fat body of Hsl^b24 homozygous larvae is enhanced if they are also mutant for bmm¹.

The large lipid droplet phenotype seen in Lsd-1³⁸ larvae is slightly enhanced by Hsl^b24.

(Bi et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Hsl^b24

(Heier et al., 2021)

dHSL^b24

(Bi et al., 2012)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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