FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\RimEx73
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General Information
Symbol
Dmel\RimEx73
Species
D. melanogaster
Name
FlyBase ID
FBal0280330
Feature type
allele
Associated gene
Dmel\Rim
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Graf et al., 2012)
Progenitor genotype
P{EPgy2}RimEY05246
(Graf et al., 2012)
Cytology
Description

Imprecise excision of the progenitor insertion, resulting in a 13kb deletion that removes part of Rim, including the PDZ and C[[2]]A domains.

(Graf et al., 2012)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The neurotransmission across neuromuscular junctions in third instar larvae, assessed by excitatory junction potential amplitude and quantal content, is significantly impaired in Rim103/RimEx73 transheterozygotes, but not in Rim103 heterozygotes, as compared to controls.

      (Bruckner et al., 2017)

      Homozygous and RimEx73/Df(3R)ED5785 larvae show no gross morphological defects at the neuromuscular junction. Mutant boutons at the RimEx73/Df(3R)ED5785 neuroumuscular junction have normal active zone length, T-bar width and number of T-bars per active zone. There is a small decrease in the number of T-bars per bouton perimeter and in the number of active zones per bouton perimeter.

      The average evoked excitatory junction current (EJC) amplitude at the neuromuscular junction is reduced by approximately 75% in RimEx73/Df(3R)ED5785 larvae compared to wild type. The average amplitude and frequency of the spontaneous mEJC is not significantly different from normal. There is a reduction in quantal content compared to wild type.

      Cumulative amplitude analysis shows that the size of the readily releasable pool of vesicles at the neuromuscular junction is reduced in RimEx73/Df(3R)ED5785 larvae compared to wild type.

      (Graf et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      Expression of RimScer\UAS.cGa under the control of Scer\GAL4VGlut.PD partially rescues the reduction of the amplitude of the evoked excitatory junction current which is seen at the neuromuscular junction in RimEx73/Df(3R)ED5785 larvae.

      (Graf et al., 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      RIMEx73
      (Graf et al., 2012)
      RIMex73
      (Bruckner et al., 2017)
      RimEx73
      rimEx73
      (Paul et al., 2022)
      rimKO
      (Paul et al., 2022)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)