FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\MMEUAS.cIa
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General Information
Symbol
Hsap\MMEUAS.cIa
Species
H. sapiens
Name
Saccharomyces cerevisiae UAS construct a of Iijima-Ando
FlyBase ID
FBal0280374
Feature type
allele
Associated gene
Hsap\MME
Associated Insertion(s)
Carried in Construct
P{UAS-MME.I}
Key Links
Transgenic product class
cDNA
(Iijima-Ando et al., 2008)
wild_type
(Iijima-Ando et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Iijima-Ando et al., 2008)
wild_type
(Iijima-Ando et al., 2008)
Mutagen
in vitro construct
(Iijima-Ando et al., 2008)
Progenitor genotype
Carried in construct
P{UAS-MME.I}
Cytology
Description

UASt regulatory sequences drive expression of a Hsap\MME cDNA.

(Iijima-Ando et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\MME
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  neurodegenerative disease
      CEA
      (Iijima-Ando et al., 2008)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Alzheimer's disease
      modeled by Hsap\APPAβ42.UAS.Tag:SS(rPENK)
      (Iijima-Ando et al., 2008)
      Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
       

      Neuronal expression of Hsap\MMEScer\UAS.cIa efficiently suppresses intraneuronal accumulation of Aβ42 protein in Drosophila expressing the Hsap\APPAβ1-42.Scer\UAS.cIa transgene. However, neuronal overexpression of Hsap\MMEScer\UAS.cIa in Drosophila (in the absence of Hsap\APP overexpression) results in age-dependent axon degeneration and a shortened lifespan.

      (Iijima-Ando et al., 2008)
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing Hsap\MMEScer\UAS.cIa under the control of Scer\GAL4elav-C155 have a shortened lifespan compared to controls. The brains of 56 day-old flies show neurodegeneration in specific neuropil regions, including the superior lateral protocerebrum, as indicated by the many vacuoles in the brain compared to controls. Degeneration is age-dependent, as no vacuoles are seen in young (8 day old) flies. No significant cell body loss is seen. At the ultrastructural level, highly swollen axons are seen in the brains of flies expressing Hsap\MMEScer\UAS.cIa under the control of Scer\GAL4elav-C155, and this is not seen in controls.

      (Iijima-Ando et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of Hsap\MMEScer\UAS.cIa dramatically suppresses the neuron loss seen in the brains of 28 day old flies expressing Hsap\APPAβ1-42.Scer\UAS.cIa under the control of Scer\GAL4elav-C155. Fewer vacuoles are seen in the cell body regions. The reduction in lifespan is not rescued.

      (Iijima-Ando et al., 2008)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Hsap\MMEScer\UAS.cIa
      Hsap\MMEUAS.cIa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Iijima-Ando
      Secondary FlyBase IDs
        References (1)