FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\SRSF3UAS.cXa
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General Information
Symbol
Hsap\SRSF3UAS.cXa
Species
H. sapiens
Name
Saccharomyces cerevisiae UAS construct a of Xu
FlyBase ID
FBal0280379
Feature type
allele
Associated gene
Hsap\SRSF3
Associated Insertion(s)
Carried in Construct
P{UAS-SRSF3.X}
Key Links
Transgenic product class
wild_type
(Xu et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Xu et al., 2008)
Mutagen
in vitro construct
(Xu et al., 2008)
Progenitor genotype
Carried in construct
P{UAS-SRSF3.X}
Cytology
Description

UAS regulatory sequences drive expression of Hsap\SRSF3.

(Xu et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsap\SRSF3
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Hsap\SRSF3Scer\UAS.cXa under the control of Scer\GAL4ptc-559.1 induces defects in sexual differentiation, where characteristics of both sexes are observed. Female flies show the appearance of male-like clasper bristles together with reduced number of vaginal bristles, which normally present as two rows flanking the female genitalia. Additional defects include abnormal development of the anus.

      When Hsap\SRSF3Scer\UAS.cXa is expressed under the control of Scer\GAL4elav.PU a male-like pigmentation pattern is seen in the posterior abdominal segment of females, which normally lacks such pigmentation. Female flies are also sterile.

      Expression of Hsap\SRSF3Scer\UAS.cXa under the control of Scer\GAL4GMR.PF induces a rough eye phenotype.

      (Xu et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Hsap\SRSF3Scer\UAS.cXa
      Hsap\SRSF3UAS.cXa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Xu
      Secondary FlyBase IDs
        References (1)