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General Information
Symbol
Dmel\TrlHsp83.GAGA-519
Species
D. melanogaster
Name
FlyBase ID
FBal0280396
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
hsp83:GAGA-519
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

A Hsp83 promoter drives expression of the GAGA-519 isoform of Trl.

Allele components
Product class / Tool use(s)
Regulatory region(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Approximately 20% of surviving male flies expressing TrlHsp83.GAGA-519 in a Trl109.2/Trl18.1 mutant background show a transformation of the sixth abdominal segment towards the fifth.

Trl109.2/Trl18.1 mutant females expressing four copies of TrlHsp83.GAGA-519 exhibit egg laying defects, laying approximately 12 eggs per 24 hours, compared to around 25 in wild type.

Approximately 70% of embryos produced by Trl109.2/Trl18.1 mutant females expressing four copies of TrlHsp83.GAGA-519 are able to hatch.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Adding at least one copy of the TrlHsp83.GAGA-519 transgene allows the recovery of a much higher frequency of homozygous Trl13C escapers that are also heterozygous for lolalk02512 (up to approximately 80% when four copies of the transgene are added).

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of TrlHsp83.GAGA-519 rescues the egg chamber phenotypes seen in Trlen82/TrlR85 mutant females.

Expression of TrlHsp83.GAGA-519 partially rescues the lethality seen in Trl13C/TrlR67 mutants, with a survival rate of between 10 and 20% depending on the insertion line.

Expression of one or two copies of TrlHsp83.GAGA-519 has no effect on the lethality associated with Trl109.2/Trl18.1 mutants. However expression of four copies is able to partially rescue the phenotype, with 10% of flies surviving.

Expression of two copies of TrlHsp83.GAGA-519 and two copies of TrlHsp83.GAGA-581 partially rescues the lethality associated with Trl109.2/Trl18.1 mutants, with approximately 40% of flies surviving.

Expression of two copies of TrlHsp83.GAGA-519 and two copies of TrlHsp83.GAGA-581 partially rescues the lethality associated with Trl109.2/TrlR67 mutants, with approximately 70% of flies surviving.

Expression of a single copy of TrlHsp83.GAGA-519 partially rescues the abdominal segment transformation seen in Trl13C mutant males.

Expression of a single copy of TrlHsp83.GAGA-519 partially rescues the reduction in egg production seen in Trl13C mutant females.

Expression of TrlHsp83.GAGA-519 partially rescues the lethality seen in embryos produced by homozygous Trl13C mutant mothers.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
TrlHsp83.GAGA-519
Name Synonyms
Secondary FlyBase IDs
    References (5)