FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\orb2RBD.UAS.B
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General Information
Symbol
Dmel\orb2RBD.UAS.B
Species
D. melanogaster
Name
FlyBase ID
FBal0280515
Feature type
allele
Associated gene
Dmel\orb2
Associated Insertion(s)
Carried in Construct
P{UAS-orb2.B.RBD}
Also Known As
UAS-orb2BRBD*
Key Links
Transgenic product class
missense_variant
(Krüttner et al., 2012)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Krüttner et al., 2012)
Mutagen
in vitro construct
(Krüttner et al., 2012)
Progenitor genotype
Carried in construct
P{UAS-orb2.B.RBD}
Cytology
Description

UAS regulatory sequences drive expression of an orb2 isoform B cDNA in which two mutations have been introduced in the RBD domain; Y492A and F494A.

(Krüttner et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
orb2
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of orb2RBD.Scer\UAS.B under the control of Scer\GAL4Mef2.247 (restricted to the adult stages using Scer\GAL80ts.αTub84B) fails to rescue the long term memory defects seen in orb2::Mmus\Cpeb2RBD.T:Avic\GFP mutant flies exposed to a courtship conditioning paradigm.

      (Krüttner et al., 2012)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      orb2RBD.Scer\UAS.B
      orb2RBD.UAS.B
      Name Synonyms
      Secondary FlyBase IDs
        References (2)