FlyBase Allele Report: Dmel\CtBP[RNAi.UAS.HIZ]

General Information

Symbol

Dmel\CtBP^RNAi.UAS.HIZ

Species

D. melanogaster

Name

FlyBase ID

FBal0280613

Feature type

allele

Associated gene

Dmel\CtBP

Associated Insertion(s)

Carried in Construct

P{UAS-CtBP.RNAi.HIZ}

Key Links

Transgenic product class

RNAi_reagent

(Stern et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Stern et al., 2009)

Mutagen

in vitro construct

(Stern et al., 2009)

Progenitor genotype

Carried in construct

P{UAS-CtBP.RNAi.HIZ}

Cytology

Description

UAS regulates expression of inverted repeats of a 360bp fragment of CtBP, separated by the 1bk first intron of h, that targets CtBP for RNAi.

(Stern et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

CtBP

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell polarity, with Scer\GAL4^ap-md544

(Stern et al., 2009)

Phenotype Manifest In

notal microchaeta, with Scer\GAL4^ap-md544

(Stern et al., 2009)

posterior dorsocentral bristle, with Scer\GAL4^ap-md544

(Stern et al., 2009)

Detailed Description

Statement

Reference

Scer\GAL4^ap-md544-mediated expression of CtBP^{dsRNA.Scer\UAS.HIZ} causes loss of posterior dorsocentral bristles and tufted microchaeta bristles. Some of the microchaetes are either missing or disorientated.

A putative cell polarity abnormality of the microchaetes is observed when CtBP^{dsRNA.Scer\UAS.HIZ} is expressed using Scer\GAL4^ap-md544.

(Stern et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

CtBP^RNAi.UAS.HIZ

CtBP^{dsRNA.Scer\UAS.HIZ}

CtBP^{dsRNA.UAS.HIZ}

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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