FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Apc2Δ15Δ20.EGFP
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General Information
Symbol
Dmel\Apc2Δ15Δ20.EGFP
Species
D. melanogaster
Name
FlyBase ID
FBal0280744
Feature type
allele
Associated gene
Dmel\Apc2
Associated Insertion(s)
Carried in Construct
PBac{Apc2-EGFP.Δ15Δ20}
Key Links
Transgenic product class
inframe_deletion
(Roberts et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Roberts et al., 2011)
Mutagen
in vitro construct
(Roberts et al., 2011)
Progenitor genotype
Carried in construct
PBac{Apc2-EGFP.Δ15Δ20}
Cytology
Description

The endogenous Apc2 promoter drives expression of a deleted form of Apc2 which lacks amino acid residues 497-535, 595-672 and 737-889 and which is tagged at the N-terminal end with EGFP.

(Roberts et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
Apc2
Encoded product / tool
Apc2
Tagged with
EGFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Apc2Δ15Δ20.T:Avic\GFP-EGFP does not rescue the cuticle defects of embryos derived from Apc2g10 ApcQ8 males crossed to females containing double homozygous germline clones. Apc2Δ15Δ20.T:Avic\GFP-EGFP may show some dominant negative activity, as 82% embryonic lethality is seen, suggesting that the ability of paternally supplied Apc[+] and Apc2[+] to rescue embryonic lethality is compromised.

      (Roberts et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      Apc2Δ15Δ20.EGFP fails to rescue Apc2g10

      (Roberts et al., 2011)
      Comments

      Apc2Δ15Δ20.T:Avic\GFP-EGFP fails to rescue the cuticle defects of embryos lacking both maternal and zygotic Apc2[+] function (homozygous Apc2g10 embryos derived from Apc2g10 females). The embryonic lethality of these Apc2 mutants is also not rescued.

      (Roberts et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Apc2Δ15Δ20.EGFP
      Apc2Δ15Δ20.T:Avic\GFP-EGFP
      Name Synonyms
      Secondary FlyBase IDs
        References (2)