FB2026_02 , released June 18, 2026
Allele: Dmel\kukhs.PB
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General Information
Symbol
Dmel\kukhs.PB
Species
D. melanogaster
Name
heat shock construct of Brandt
FlyBase ID
FBal0280960
Feature type
allele
Associated gene
Dmel\kuk
Associated Insertion(s)
Carried in Construct
P{hs-kuk.B}
Key Links
Transgenic product class
wild_type
(Brandt et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Brandt et al., 2008)
Mutagen
in vitro construct
(Brandt et al., 2008)
Progenitor genotype
Carried in construct
P{hs-kuk.B}
Cytology
Description

Heat shock promoter sequences drive expression of the kuk coding sequence and part of its 3' untranslated region.

(Brandt et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
Encoded product / tool
kuk
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The longitudinal muscle cells of 3 day old adult flies expressing 6 genomic copies of kukhs.PB display nuclear phenotypes usually only observed during aging, with loss of peripheral heterochromatin, separation of the inner and outer nuclear membrane, accumulation of ring like structures and a strong increase of dark material in the nucleoplasm are all observed.

      Expression of kukhs.PB induces lobulation of the nuclear membrane in stage 9 embryos.

      Flies expressing 4 or 6 genomic copies of kukhs.PB have a reduced lifespan compared to controls.

      (Brandt et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      kukhs.PB
      Name Synonyms
      heat shock construct of Brandt
      Secondary FlyBase IDs
        References (1)