FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\IDEUAS.cTa
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General Information
Symbol
Hsap\IDEUAS.cTa
Species
H. sapiens
Name
Saccharomyces cerevisiae UAS construct a of Tsuda
FlyBase ID
FBal0280988
Feature type
allele
Associated gene
Hsap\IDE
Associated Insertion(s)
Carried in Construct
P{UAS-hIDE}
Key Links
Transgenic product class
wild_type
(Tsuda et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Tsuda et al., 2010)
Mutagen
in vitro construct
(Tsuda et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-hIDE}
Cytology
Description

UASt regulatory sequences drive expression of Hsap\IDE.

(Tsuda et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\IDE
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Alzheimer's disease
      modeled by Hsap\APP695.UAS, Hsap\BACE1UAS.cGa
      (Tsuda et al., 2010)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mis-expression of Hsap\IDEScer\UAS.cTa in insulin producing cells using Scer\GAL4Ilp2.PR as a driver results in reduced body weight of the adult flies compared with wild-type.

      Forced expression of IdeScer\UAS.cTa in the developing wing imaginal disc using Scer\GAL4sd-SG29.1 results in the reduction of wing size compared with wild-type.

      (Tsuda et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Forced expression of Hsap\IDEScer\UAS.cTa under the control of Scer\GAL4elav-C155 can suppress the neuronal degeneration induced by the expression of Hsap\BACE1Scer\UAS.cGa.

      The reduced lifespan of flies co-expressing Hsap\BACE1Scer\UAS.cGa and Hsap\APP695.Scer\UAS under the control of Scer\GAL4elav-C155 is partially suppressed by the co-expression of Hsap\IDEScer\UAS.cTa.

      The ectopic wing vein phenotype induced by co-expressing Hsap\BACE1Scer\UAS.cGa and Hsap\APP695.Scer\UAS under the control of Scer\GAL4Act5C.PI is suppressed by the co-expression of Hsap\IDEScer\UAS.cTa.

      (Tsuda et al., 2010)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Hsap\IDEScer\UAS.cTa
      Hsap\IDEUAS.cTa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Tsuda
      Secondary FlyBase IDs
        References (1)