FB2026_02 , released June 18, 2026
Allele: Dmel\tbrd-11
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General Information
Symbol
Dmel\tbrd-11
Species
D. melanogaster
Name
FlyBase ID
FBal0281059
Feature type
allele
Associated gene
Dmel\tbrd-1
Associated Insertion(s)
P{EPgy2}tbrd-11
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Leser et al., 2012)
Progenitor genotype
Associated Insertion(s)
P{EPgy2}tbrd-11
Cytology
Description

Insertion into tbrd-1. This results in a premature translation after 281 amino acid residues, with the protein produced consisting of 262 amino acids of tbrd-1 and 19 amino acids encoded by the insertion.

(Leser et al., 2012)
Allele components
Component
Use(s)
Inserted element
P{EPgy2}
Regulatory region(s)
UASp
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous, tbrd-11/Df(3R)ED10893 and tbrd-11/Df(3R)Exel9014 males are completely sterile.

      The Nebenkern is larger than the nucleus in early round spermatids in homozygous males. The nuclei of mutant spermatids remain small and round (in contrast to the elongated shape that develops in wild type). In addition, spermatid nuclei are scattered throughout elongated bundles of flagella instead of being clustered at one end as in wild type. Investment cones are formed in homozygous mutants, but individualisation complexes are never seen.

      (Leser et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      tbrd-11 is rescued by tbrd-1EGFP

      (Leser et al., 2012)
      Not rescued by

      tbrd-11 is not rescued by tbrd-1Δc.EGFP

      (Leser et al., 2012)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      tbrd-11
      (Hundertmark et al., 2019, Kimura and Loppin, 2015, Theofel et al., 2014, Leser et al., 2012)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)