FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\E(comt6)21E21E
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General Information
Symbol
Dmel\E(comt6)21E21E
Species
D. melanogaster
Name
FlyBase ID
FBal0281704
Feature type
allele
Associated gene
E(comt6)21E
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Sanyal and Krishnan, 2012)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      E(comt[6])21E[+]/E(comt6)21E21E is an enhancer of paralytic | heat sensitive phenotype of comt6

      (Sanyal and Krishnan, 2012)
      NOT Enhancer of
      Statement
      Reference

      E(comt[6])21E[+]/E(comt6)21E21E is a non-enhancer of paralytic | heat sensitive phenotype of comtts53

      (Sanyal and Krishnan, 2012)

      E(comt[6])21E[+]/E(comt6)21E21E is a non-enhancer of paralytic | heat sensitive phenotype of comtts17

      (Sanyal and Krishnan, 2012)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      E(comt6)21E21E/+ enhances the temperature sensitive paralytic phenotype of comt6. The time taken for flies to paralyse at 34.5[o]C is significantly decreased and the time taken for complete recovery after exposure to 38[o]C for 1 minute is prolonged. comt6 E(comt6)21E21E/+ flies paralyse within 3 minutes at 32[o]C (comt6 single mutants do not paralyse under these conditions).

      (Sanyal and Krishnan, 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      21E
      (Sanyal and Krishnan, 2012)
      E(comt6)21E21E
      Name Synonyms
      Secondary FlyBase IDs
        References (1)