FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Chro17a
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General Information
Symbol
Dmel\Chro17a
Species
D. melanogaster
Name
FlyBase ID
FBal0281968
Feature type
allele
Associated gene
Dmel\Chro
Associated Insertion(s)
P{SUPor-P-Δ17a}Chro17a
Carried in Construct
Key Links
Allele class

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Wasser et al., 2007)
Mutagen
Delta2-3 transposase
(Wasser et al., 2007)
Progenitor genotype
P{SUPor-P}ChroKG03258
(Wasser et al., 2007)
Associated Insertion(s)
P{SUPor-P-Δ17a}Chro17a
Cytology
Description

Imprecise excision of the progenitor insertion. Internal sequences of the insertion have been removed, leaving the P-element ends and flanking genomic sequence intact.

(Wasser et al., 2007)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      100% of homozygous pupae show a marked reduction of muscle histolysis in the abdomen, with debris often persisting till the pharate stage. The breakdown of the dorsal external oblique muscles is incomplete at the onset of head eversion. As a result, the anterior part of the abdomen remains attached to the epidermis and muscle contractions propel the abdomen forwards instead of causing it to retract to the posterior end of the puparium as in wild type. This creates a gap in the puparium and limits space for the thorax and head. The thorax is shifted anteriorly in 41% of mutants. 51% of mutant animals reach the pharate adult stage. The temporary dorsal internal oblique muscles of the abdomen are either absent or show morphological defects in 97% of these pharate adults.

      (Wasser et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      Chro17a has lethal phenotype, suppressible | partially by easthop-7/east[+]

      (Wasser et al., 2007)
      NOT Suppressor of
      Statement
      Reference

      Chro17a/Chro[+] is a non-suppressor of lethal phenotype of easthop-7

      (Wasser et al., 2007)

      Chro17a/Chro17a is a non-suppressor of lethal phenotype of easthop-7

      (Wasser et al., 2007)
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Chro71/Chro17a has neuroblast | third instar larval stage phenotype, suppressible | partially by pros[+]/pros17

      (Li et al., 2017)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The central brain neuroblast reactivation defects (manifested by the retention of cellular extensions) observed in Chro71/Chro17a larvae is significantly suppressed by pros17 heterozygosity.

      (Li et al., 2017)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Chro17a
      (Wasser et al., 2007)
      chro17a
      (Li et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)