FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\east1-1902.UAS.GFP
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General Information
Symbol
Dmel\east1-1902.UAS.GFP
Species
D. melanogaster
Name
FlyBase ID
FBal0282347
Feature type
allele
Associated gene
Dmel\east
Associated Insertion(s)
Carried in Construct
P{UAS-east.1-1902.GFP}
Key Links
Transgenic product class
inframe_deletion
(Chinta et al., 2012)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Chinta et al., 2012)
Mutagen
in vitro construct
(Chinta et al., 2012)
Progenitor genotype
Carried in construct
P{UAS-east.1-1902.GFP}
Cytology
Description

UAS regulatory sequences drive expression of the N-terminal 1902 amino acid residues of east, tagged with GFP.

(Chinta et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
east
Tagged with
GFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The dorsal abdominal muscles of larvae expressing east1-1902.Scer\UAS.T:Avic\GFP under the control of Scer\GAL4Mef2.PR appear morphologically normal. However, during the early pupal stage, these animals show a delay in the apoptosis of the dorsal external oblique muscles, with the mutant muscles remaining intact until 24 hours after puparium formation (APF) (the muscles have completed histolysis by 12 hours APF in wild type). The remodelling of larval dorsal internal oblique muscles into adult muscles is also abnormal in these animals: the reduction in muscle diameter is delayed compared to wild type and the muscles show irregular morphologies and orientations.

      (Chinta et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      east1-1902.Scer\UAS.T:Avic\GFP
      east1-1902.UAS.GFP
      Name Synonyms
      Secondary FlyBase IDs
        References (2)