FB2026_02 , released June 18, 2026
Allele: Dmel\kay::DpsekayUAS.α
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General Information
Symbol
Dmel\kay::Dpse\kayUAS.α
Species
D. melanogaster
Name
FlyBase ID
FBal0282349
Feature type
allele
Associated gene
kay::Dpse\kay
Associated Insertion(s)
Carried in Construct
P{UAS-Dpse\kay::kay.α}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Ling et al., 2012)
Progenitor genotype
Carried in construct
P{UAS-Dpse\kay::kay.α}
Cytology
Description

UAS regulatory sequences drive expression of a chimeric protein which consists of the D. melanogaster kay α isoform in which the N-terminal exon has been replaced with the corresponding sequence from the D. pseudoobscura Dpse\kay α isoform. The mRNA produced is sufficiently divergent in sequence from the D. melanogaster kay α isoform to be resistant to the dsRNA produced by the P{NIG.15507R} RNAi construct which targets the N-terminal exon.

(Ling et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
kay::Dpse\kay
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of kay::Dpse\kayScer\UAS.α under the control of Scer\GAL4P2.4.Pdf in the presence of Dcr-2Scer\UAS.cDa (which increases RNAi efficiency) does not shorten the period of locomotor activity (measured in flies kept under constant darkness conditions).

      (Ling et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Dcr-2UAS.cDa, kay::Dpse\kayUAS.α, Scer\GAL4P2.4.Pdf rescues kayNIG.15507R

      (Ling et al., 2012)
      Comments

      Co-expression of kay::Dpse\kayScer\UAS.α rescues the long period phenotype seen in flies expressing kayNIG.15507R under the control of Scer\GAL4P2.4.Pdf in the presence of Dcr-2Scer\UAS.cDa (which increases RNAi efficiency).

      (Ling et al., 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      kay::Dpse\kayScer\UAS.α
      kay::Dpse\kayUAS.α
      Name Synonyms
      Secondary FlyBase IDs
        References (1)