FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mtgC2-3.UAS.EGFP
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General Information
Symbol
Dmel\mtgC2-3.UAS.EGFP
Species
D. melanogaster
Name
FlyBase ID
FBal0282535
Feature type
allele
Associated gene
Dmel\mtg
Associated Insertion(s)
Carried in Construct
P{UAS-mtg.C2-3.GFP}
Key Links
Transgenic product class
missense_variant
(Rushton et al., 2012)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Rushton et al., 2012)
Mutagen
in vitro construct
(Rushton et al., 2012)
Progenitor genotype
Carried in construct
P{UAS-mtg.C2-3.GFP}
Cytology
Description

UAS regulatory sequences drive expression of mtg which contains Cys to Ala mutations in conserved Cys residues 2 and 3 in the carbohydrate-binding domain. The protein is tagged at the C-terminal end with EGFP.

(Rushton et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
mtg
Tagged with
EGFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      mtgC2-3.UAS.EGFP/Scer\GAL4da.G32 partially rescues mtg1

      (Rushton et al., 2012)
      Comments

      Expression of mtgC2-3.Scer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4da.G32 rescues limited embryonic movement and hatching in mtg1 homozygotes, although the larvae die shortly after hatching. Glutamate-gated current amplitudes are restored to wild-type levels at the neuromuscular junctions of rescued embryos.

      (Rushton et al., 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      mtgC2-3.Scer\UAS.T:Avic\GFP-EGFP
      mtgC2-3.UAS.EGFP
      Name Synonyms
      Secondary FlyBase IDs
        References (1)