FlyBase Allele Report: Dmel\TyrRS-m[tOre.V275A]

General Information

Symbol

Dmel\TyrRS-m^tOre.V275A

Species

D. melanogaster

Name

FlyBase ID

FBal0282673

Feature type

allele

Associated gene

Dmel\TyrRS-m

Associated Insertion(s)

Carried in Construct

PBac{TyrRS-m.Ore.V275A}

Key Links

Transgenic product class

missense_variant

(Meiklejohn et al., 2013)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Meiklejohn et al., 2013)

Mutagen

in vitro construct

(Meiklejohn et al., 2013)

Progenitor genotype

TyrRS-m^tOre

(Meiklejohn et al., 2013)

Carried in construct

PBac{TyrRS-m.Ore.V275A}

Cytology

Description

A 2326bp genomic fragment encompassing TyrRS-m, isolated from the Oregon R strain. A V275A amino acid replacement has been introduced into the TyrRS-m coding region.

(Meiklejohn et al., 2013)

Allele components

Component

Use(s)

Regulatory region(s)

TyrRS-m

Encoded product / tool

TyrRS-m

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

When the 'simw[501]' mitochondrial genome, which contains the Dsim\mt:tRNA:Y^w501 allele, is paired with the nuclear Aats-tyr-m^tOre.V275A rescue allele (Aats-tyr-m^tOre.V275A, Df(2R)BSC606), scutellar bristle length is intermediate between the relatively shorter scutellar bristles produced by pairing with the Aats-tyr-m^tOre mutant allele (Aats-tyr-m^tOre, Df(2R)BSC606), and the relatively longer scutellar bristles produced by pairing with the wild type nuclear Aats-tyr-m^tAutW132 allele (Aats-tyr-m^tAutW132, Df(2R)BSC606).

Flight performance is relatively strong while climbing ability is intermediate in flies in which the 'simw[501]' mitochondrial genome, which contains the Dsim\mt:tRNA:Y^w501 allele, is paired with the nuclear Aats-tyr-m^tOre.V275A rescue allele (Aats-tyr-m^tOre.V275A, Df(2R)BSC606). The morphology of indirect flight muscle mitochondria is only weakly affected.

(Holmbeck et al., 2015)

Complementation and Rescue Data

Comments

Aats-tyr-m^tOre.V275A rescues the developmental delay seen in mitochondrial-nuclear hybrid strains containing the D. melanogaster nuclear genome and a D. simulans mitochondrial genome where the nuclear genome contains Aats-tyr-m^Ore/Df(2R)BSC606 and the mitochondrial genome contains Dsim\mt:tRNA:Y^w501.

(Meiklejohn et al., 2013)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Aats-tyr-m^tOre.V275A

TyrRS-m^tOre.V275A

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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