FlyBase Allele Report: Dmel\E(spl)m8-HLH[Δgro.UAS]

General Information

Symbol

Dmel\E(spl)m8-HLH^Δgro.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0282765

Feature type

allele

Associated gene

Dmel\E(spl)m8-HLH

Associated Insertion(s)

Carried in Construct

P{UAS-E(spl)m8-HLH.ΔGro}

Key Links

Transgenic product class

stop_gained

(Kahali et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

stop_gained

(Kahali et al., 2009)

Mutagen

in vitro construct

(Kahali et al., 2009)

Progenitor genotype

Carried in construct

P{UAS-E(spl)m8-HLH.ΔGro}

Cytology

Description

UAS drives expression of E(spl)m8-HLH in which a STOP codon is substituted in place of the W176 of the WRPW motif, thus removing this motif and abolishing gro protein binding.

(Kahali et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

E(spl)m8-HLH

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of E(spl)m8-HLH^{Δgro.Scer\UAS} with Scer\GAL4^sca-537.4 has no effect on the eye or interommatidial bristles or scutellar macrochaetes.

Expression of E(spl)m8-HLH^{Δgro.Scer\UAS} with Scer\GAL4^455.2 has no effect on scutellar macrochaetes.

(Kahali et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

E(spl)m8-HLH^Δgro.UAS/Scer\GAL4^h-H10 is a non-enhancer of eye phenotype of N^spl-1

(Kahali et al., 2009)

E(spl)m8-HLH^Δgro.UAS/Scer\GAL4^sca-109-68 is a non-enhancer of eye phenotype of N^spl-1

(Kahali et al., 2009)

NOT Suppressor of

Statement

Reference

E(spl)m8-HLH^Δgro.UAS/Scer\GAL4^h-H10 is a non-suppressor of eye phenotype of N^spl-1

(Kahali et al., 2009)

E(spl)m8-HLH^Δgro.UAS/Scer\GAL4^sca-109-68 is a non-suppressor of eye phenotype of N^spl-1

(Kahali et al., 2009)

E(spl)m8-HLH^Δgro.UAS/Scer\GAL4^h-H10 is a non-suppressor of scutellar bristle | ectopic phenotype of N^spl-1

(Kahali et al., 2009)

E(spl)m8-HLH^Δgro.UAS/Scer\GAL4^h-H10 is a non-suppressor of scutellar bristle phenotype of N^spl-1

(Kahali et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to rescue

Scer\GAL4^455.2/E(spl)m8-HLH^Δgro.UAS fails to rescue E(spl)m8-HLH^UAS.cUa

(Kahali et al., 2009)

Comments

Co-expression of E(spl)m8-HLH^{Δgro.Scer\UAS} does not attenuate the potent loss of scutellar bristles seen in E(spl)m8-HLH^Scer\UAS.cUa Scer\GAL4^455.2 flies.

(Kahali et al., 2009)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

E(spl)m8-HLH^{Δgro.Scer\UAS}

E(spl)m8-HLH^Δgro.UAS

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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