FB2026_02 , released June 18, 2026
Allele: Dmel\Dbp21E21
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General Information
Symbol
Dmel\Dbp21E21
Species
D. melanogaster
Name
FlyBase ID
FBal0283015
Feature type
allele
Associated gene
Dmel\Dbp21E2
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Hibbard and O'Tousa, 2012)
Progenitor genotype
Cytology
Description

Nucleotide substitution: C173T.

(Hibbard and O'Tousa, 2012)

Amino acid replacement: ?58term.

(Hibbard and O'Tousa, 2012)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:811,807..811,807 [+]
Nucleotide change:

C811807T

Reported nucleotide change:

C173T

Amino acid change:

Q58term | Dbp21E2-PA

Reported amino acid change:

?58term

(Hibbard and O'Tousa, 2012)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The pseudopupil is disorganised in mosaic animals containing homozygous eyes (generated using eyFLP). The compound eye is roughened and slightly reduced in size compared to wild type. Photoreceptors within the homozygous eyes show a progressive retinal degeneration phenotype, with the R7 photoreceptor cell being less affected than the R1-R6 cells. The retinal degeneration is not light-dependent.

      The electroretinogram of 4 hour old mosaic flies containing homozygous eyes has a small depolarisation and a small recovery phase compared to wild type.

      (Hibbard and O'Tousa, 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhanced by
      NOT suppressed by
      Phenotype Manifest In
      NOT Enhanced by
      Statement
      Reference

      Dbp21E21 has retina | somatic clone | progressive phenotype, non-enhanceable by ninaE17/ninaE17

      (Hibbard and O'Tousa, 2012)
      NOT suppressed by
      Statement
      Reference

      Dbp21E21 has retina | somatic clone | progressive phenotype, non-suppressible by ninaE17/ninaE17

      (Hibbard and O'Tousa, 2012)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The progression of retinal degeneration seen in mosaic animals containing homozygous Dbp21E21 eyes is not altered if the flies are also homozygous for ninaE17.

      (Hibbard and O'Tousa, 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      Dbp21E22

      (Hibbard and O'Tousa, 2012)
      Rescued by

      Dbp21E21 is rescued by Dbp21E2+t2.9

      (Hibbard and O'Tousa, 2012)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Dbp21E21
      (Hibbard and O'Tousa, 2012)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)