FlyBase Allele Report: Hsap\BCAS2[UAS.wt]

General Information

Symbol

Hsap\BCAS2^UAS.wt

Species

H. sapiens

Name

FlyBase ID

FBal0283024

Feature type

allele

Associated gene

Hsap\BCAS2

Associated Insertion(s)

Carried in Construct

P{UAS-hBCAS2.wt}

Also Known As

UAS-hBCAS2

Key Links

Transgenic product class

wild_type

(Chen et al., 2013)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Chen et al., 2013)

Mutagen

in vitro construct

(Chen et al., 2013)

Progenitor genotype

Carried in construct

P{UAS-hBCAS2.wt}

Cytology

Description

UASt regulatory sequences drive expression of wild-type Hsap\BCAS2.

(Chen et al., 2013)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Hsap\BCAS2

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Hsap\BCAS2^UAS.wt, Scer\GAL4^Act5C.PU is a suppressor | partially of lethal phenotype of BCAS2^GD11494, Scer\GAL4^Act5C.PU

(Chen et al., 2013)

Hsap\BCAS2^UAS.wt, Scer\GAL4^Bx-MS1096 is a suppressor | partially of visible phenotype of BCAS2^GD11494, Scer\GAL4^Bx-MS1096

(Chen et al., 2013)

Hsap\BCAS2^UAS.wt, Scer\GAL4^ap-md544 is a suppressor | partially of visible phenotype of BCAS2^GD11494, Scer\GAL4^ap-md544

(Chen et al., 2013)

Hsap\BCAS2^UAS.wt, Scer\GAL4^en.PU is a suppressor of increased cell death phenotype of BCAS2^GD11494, Scer\GAL4^en.PU

(Chen et al., 2013)

Phenotype Manifest In

Suppressor of

Statement

Reference

Hsap\BCAS2^UAS.wt, Scer\GAL4^Bx-MS1096 is a suppressor | partially of wing phenotype of BCAS2^GD11494, Scer\GAL4^Bx-MS1096

(Chen et al., 2013)

Hsap\BCAS2^UAS.wt, Scer\GAL4^Bx-MS1096 is a suppressor of scutellum phenotype of BCAS2^GD11494, Scer\GAL4^Bx-MS1096

(Chen et al., 2013)

Hsap\BCAS2^UAS.wt, Scer\GAL4^ap-md544 is a suppressor | partially of wing phenotype of BCAS2^GD11494, Scer\GAL4^ap-md544

(Chen et al., 2013)

Hsap\BCAS2^UAS.wt, Scer\GAL4^en.PU is a suppressor of wing disc posterior compartment phenotype of BCAS2^GD11494, Scer\GAL4^en.PU

(Chen et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Co-expression of Hsap\BCAS2^Scer\UAS.wt fully restores the scutellum margin and wing shape in animals expressing BCAS2^GD11494 under the control of Scer\GAL4^Bx-MS1096. Wing veins are only partially recovered in these flies, with the anterior crossvein being missing and the posterior crossvein being truncated.

Co-expression of Hsap\BCAS2^Scer\UAS.wt partially rescues wing shape in animals expressing BCAS2^GD11494 under the control of Scer\GAL4^ap-md544.

Co-expression of Hsap\BCAS2^Scer\UAS.wt fully suppresses the increased apoptosis seen in the posterior region of the wing disc in animals expressing BCAS2^GD11494 under the control of Scer\GAL4^en.PU.

(Chen et al., 2013)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Hsap\BCAS2^Scer\UAS.wt

Hsap\BCAS2^UAS.wt

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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