FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\WnkD420A.UAS
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General Information
Symbol
Dmel\WnkD420A.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0283036
Feature type
allele
Associated gene
Dmel\Wnk
Associated Insertion(s)
Carried in Construct
P{UAS-DWNK.D420A}
Key Links
Transgenic product class
missense_variant
(Sato and Shibuya, 2013)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Sato and Shibuya, 2013)
Mutagen
in vitro construct
(Sato and Shibuya, 2013)
Progenitor genotype
Carried in construct
P{UAS-DWNK.D420A}
Cytology
Description

UAS regulatory sequences drive expression of a kinase-dead form of Wnk (contains the amino acid replacement D420A).

(Sato and Shibuya, 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Wnk
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of WnkD420A.Scer\UAS under the control of Scer\GAL4sd.PU results in loss of wing margin and in complete disruption of abdominal differentiation in pharate adults.

      Expression of WnkD420A.Scer\UAS under the control of Scer\GAL4insc-Mz1407 caused severe defects in the peripheral nervous system of embryos.

      (Sato and Shibuya, 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of either AwhScer\UAS.cSa or frayS347D.Scer\UAS suppresses the defects in abdominal differentiation seen in pharate adults expressing WnkD420A.Scer\UAS under the control of Scer\GAL4sd.PU.

      Co-expression of frayS347D.Scer\UAS suppresses the peripheral nervous system defects seen in embryos expressing WnkD420A.Scer\UAS under the control of Scer\GAL4insc-Mz1407.

      Co-expression of AwhScer\UAS.cSa does not suppress the peripheral nervous system defects seen in embryos expressing WnkD420A.Scer\UAS under the control of Scer\GAL4insc-Mz1407.

      (Sato and Shibuya, 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      WnkD420A.Scer\UAS
      WnkD420A.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)