FlyBase Allele Report: Hsap\UCP3[UAS.cHa]

General Information

Symbol

Hsap\UCP3^UAS.cHa

Species

H. sapiens

Name

FlyBase ID

FBal0283128

Feature type

allele

Associated gene

Hsap\UCP3

Associated Insertion(s)

Carried in Construct

P{UAS-hUCP3.H}

Key Links

Transgenic product class

cDNA

(Humphrey et al., 2009)

wild_type

(Humphrey et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Humphrey et al., 2009)

wild_type

(Humphrey et al., 2009)

Mutagen

in vitro construct

(Humphrey et al., 2009)

Progenitor genotype

Carried in construct

P{UAS-hUCP3.H}

Cytology

Description

UASt drives expression of Hsap\UCP3 cDNA.

(Humphrey et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Hsap\UCP3

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal, with Scer\GAL4^Act5C.PI

(Humphrey et al., 2009)

lethal | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

(Humphrey et al., 2009)

long lived | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

(Humphrey et al., 2009)

short lived, with Scer\GAL4^da.G32

(Humphrey et al., 2009)

short lived, with Scer\GAL4^Ilp2.215-3

(Humphrey et al., 2009)

short lived | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

(Humphrey et al., 2009)

viable, with Scer\GAL4^Act5C.PI

(Humphrey et al., 2009)

viable, with Scer\GAL4^da.G32

(Humphrey et al., 2009)

viable, with Scer\GAL4^{elav.Switch.PO}

(Humphrey et al., 2009)

viable, with Scer\GAL4^Ilp2.215-3

(Humphrey et al., 2009)

Phenotype Manifest In

Detailed Description

Statement

Reference

Scer\GAL4^Act5C.PI-mediated expression of any single P{UAS-hUCP3.H} insertion line is viable, but simultaneous expression of 3x P{UAS-hUCP3.H} insertion lines is results in most animals dying as embryos.

Scer\GAL4^da.G32-mediated expression of a single P{UAS-hUCP3.H} insertion line or simultaneous expression of 3x P{UAS-hUCP3.H} insertion lines is viable.

In the presence of RU486, Scer\GAL4^{elav.Switch.PO}-mediated expression of a single P{UAS-hUCP3.H} insertion line is viable, but simultaneous expression of 3x P{UAS-hUCP3.H} insertion lines is results in most animals dying as embryos.

Scer\GAL4^Ilp2.215-3-mediated simultaneous expression of 3x P{UAS-hUCP3.H} insertion lines is viable.

Scer\GAL4^da.G32-mediated expression of 3x P{UAS-hUCP3.H} insertion lines shortens lifespan.

In the presence of RU486, Scer\GAL4^{elav.Switch.PO}-mediated expression of a single P{UAS-hUCP3.H} insertion line modestly extends maximum lifespan in females and median lifespan in males. However, simultaneous expression of 3x P{UAS-hUCP3.H} insertion lines is results in a dramatically decreased lifespan.

Scer\GAL4^Ilp2.215-3-mediated expression of 3x P{UAS-hUCP3.H} insertion lines is results in a dramatically decreased lifespan.

(Humphrey et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Hsap\UCP3^Scer\UAS.cHa

Hsap\UCP3^UAS.cHa

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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