FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mv2
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General Information
Symbol
Dmel\mv2
Species
D. melanogaster
Name
FlyBase ID
FBal0283546
Feature type
allele
Associated gene
Dmel\mv
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: W3160term.

    (Rahman et al., 2012)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    3L:1,951,824..1,951,824 [-]
    Nucleotide change:

    G1951824A

    Amino acid change:

    W3160term | mv-PB

    Reported amino acid change:

    W3160term

    Comment:

    G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation (exact site of mutation unspecified). Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

    (Rahman et al., 2012)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 1 )
        Disease
        Evidence
        References
        model of  Chediak-Higashi syndrome
        CEA
        (Rahman et al., 2012)
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
         

        mv2/Df(3L)ED4287 animals are used as the disease model.

        (Rahman et al., 2012)
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        mv2/Df(3L)ED4287 flies have eyes that appear brown compared to wild type, due to an increase in brown ommochrome and a decrease in red drospterin pigments. This phenotype is subtle in young flies, but becomes more pronounced in flies aged 20 days or more. Pigment granules of primary pigment cells are reduced in number but drastically increased in size and pigment granules in secondary and tertiary pigment cells are drastically increased in size in mv2/Df(3L)ED4287 eyes compared to controls. The structure and arrangement of the rhabdomeres appears normal.

        mv2/Df(3L)ED4287 flies show significantly reduced survival compared to controls after infection with a low dose of E. coli.

        Hemocytes isolated from mv2/Df(3L)ED4287 larvae develop over-sized late phagosomes after infection with heat-inactivated E. coli. The phagosomes are enlarged before they fuse with lysosomes. The lysosomes have abnormal tubular extensions in the mutant hemocytes.

        mv2/Df(3L)ED4287 flies show reduced starvation resistance compared to controls. Autophagosomes in the starved fat body grow beyond their normal size.

        (Rahman et al., 2012)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Fails to complement

        mv1

        (Rahman et al., 2012)
        Rescued by

        mv2/Df(3L)ED4287 is rescued by mv+tCH322-23O09

        (Rahman et al., 2012)
        Comments

        mv+tCH322-23O09 rescues the eye colour defect, immune response defects and reduced starvation resistance of mv2/Df(3L)ED4287 flies.

        (Rahman et al., 2012)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer

        Associated with: a separable lethal mutation on the chromosome.

        (Rahman et al., 2012)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        3L-85
        (Rahman et al., 2012)
        mv2
        (Rahman et al., 2012)
        Name Synonyms
        Secondary FlyBase IDs
          References (1)