FB2026_02 , released June 18, 2026
Allele: Dmel\bunM15
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General Information
Symbol
Dmel\bunM15
Species
D. melanogaster
Name
FlyBase ID
FBal0283595
Feature type
allele
Associated gene
Dmel\bun
Associated Insertion(s)
P{EP}bunM15
Carried in Construct
Key Links
Allele class

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Kim et al., 2009)
Mutagen
Delta2-3 transposase
(Kim et al., 2009)
Progenitor genotype
P{EP}Sec61γEP1511
(Kim et al., 2009)
Associated Insertion(s)
P{EP}bunM15
Cytology
Description

Mobilization of P{EP}Sec61γEP1511, resulting in an insertion in the 5' UTR of the bun-RA transcript.

(Kim et al., 2009)
Allele components
Component
Use(s)
Inserted element
P{EP}
Regulatory region(s)
UAS
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous flies show premature loss of locomotor activity and reduced lifespan.

      The alpha/beta axon lobe of the mushroom body is malformed in bunM15 brains, showing an apparent decrease in thickness; the gamma lobe is normal. The medial beta lobe, which usually stops at the midline, shows a midline-crossing phenotype in most mutant brains. The alpha'/beta' lobes of bunM15 third instar larvae appear normal.

      The alpha/beta lobe defects seen in bunM15 adult brains are apparent at 48h APF - the lobe is already thinner and doesn't increase dramatically in thickness like the wild type control.

      The alpha/beta axon lobe of the mushroom body is malformed in bunM15/bunG12085 and bunM15/bunG12937 brains.

      Scer\GAL4ey-OK107-mediated expression of bunM15 results in thicker alpha/beta lobes than wild type. The beta lobe is very thick, and midline crossing is observed.

      Mushroom body neuroblast proliferation is reduced and prematurely terminated in bunM15 mutant pupae compared to controls. The mass of Kenyon cells is also smaller in the mutants.

      (Kim et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      bunM15
      (Kim et al., 2009)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)