FB2026_02 , released June 18, 2026
Allele: Dmel\Pink1UAS.cTa
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General Information
Symbol
Dmel\Pink1UAS.cTa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Todd
FlyBase ID
FBal0283679
Feature type
allele
Associated gene
Dmel\Pink1
Associated Insertion(s)
Carried in Construct
P{UAS-Pink1.T}
Key Links
Transgenic product class
cDNA
(Todd and Staveley, 2008)
wild_type
(Todd and Staveley, 2008)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Todd and Staveley, 2008)
wild_type
(Todd and Staveley, 2008)
Mutagen
in vitro construct
(Todd and Staveley, 2008)
Progenitor genotype
Carried in construct
P{UAS-Pink1.T}
Cytology
Description

UASt regulatory sequences drive expression of a Pink1 cDNA (from clone GH20931).

(Todd and Staveley, 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Pink1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Parkinson's disease
      modeled by Hsap\SNCAUAS.cFa
      (Todd and Staveley, 2008)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Pink1Scer\UAS.cTa under the control of Scer\GAL4Ddc.PL has no effect on climbing ability or lifespan.

      Expression of Pink1Scer\UAS.cTa under the control of Scer\GAL4GMR.PF has no effect on retinal organisation at either 3 or 30 days.

      (Todd and Staveley, 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      Pink1UAS.cTa is an enhancer of visible phenotype of Hsap\SNCAUAS.cFa, Scer\GAL4GMR.PF

      (Todd and Staveley, 2008)
      Suppressor of
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Pink1UAS.cTa is an enhancer of eye phenotype of Hsap\SNCAUAS.cFa, Scer\GAL4GMR.PF

      (Todd and Staveley, 2008)
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of Pink1Scer\UAS.cTa partially suppresses the rough eye phenotype seen in Scer\GAL4GMR.PF/+ flies.

      (Todd and Staveley, 2008)
      Xenogenetic Interactions
      Statement
      Reference

      Expression of Pink1Scer\UAS.cTa completely suppresses the premature loss of climbing ability seen when Hsap\SNCAScer\UAS.cFa is expressed under the control of Scer\GAL4Ddc.PL. The lifespan of these flies is similar to controls.

      Expression of Hsap\SNCAScer\UAS.cFa enhances the rough eye phenotype seen in Scer\GAL4GMR.PF/+ flies at 29[o]C. Approximately 50% of the eye area contains fused or enlarged ommatidia. Co-expression of Pink1Scer\UAS.cTa suppresses this phenotype, returning the proportion of eye fusion to the level seen when Scer\GAL4GMR.PF is expressed alone. The retinal deterioration seen in 30 day old flies is suppressed.

      (Todd and Staveley, 2008)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Pink1Scer\UAS.cTa
      Pink1UAS.cTa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Todd
      Secondary FlyBase IDs
        References (1)